Drug Delivery Systems For Anti-Cancer Active Complexes of Some Coinage Metals

Title:Drug Delivery Systems For Anti-Cancer Active Complexes of Some Coinage Metals

Volume: 25 Issue: 4

Author(s): Ming Zhang, Camille Saint-Germain, Guiling He and Raymond Wai-Yin Sun*

Affiliation:

• Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 515063,China

Keywords: Cancer, coinage metal, copper, drug delivery system, gold, silver.

Abstract: Background: Although cisplatin and a number of platinum complexes have widely been used for the treatment of neoplasia, patients receiving these treatments have frequently suffered from their severe toxic side effects, the development of resistance with consequent relapse. In the recent decades, numerous complexes of coinage metals including that of gold, copper and silver have been reported to display promising in vitro and/or in vivo anti-cancer activities as well as potent activities towards cisplatin-resistant tumors. Nevertheless, the medical development of these metal complexes has been hampered by their instability in aqueous solutions and the nonspecific binding in biological systems.

Methods: One of the approaches to overcome these problems is to design and develop adequate drug delivery systems (DDSs) for the transport of these complexes. By functionalization, encapsulation or formulation of the metal complexes, several types of DDSs have been reported to improve the desired pharmacological profile of the metal complexes, improving their overall stability, bioavailability, anti-cancer activity and reducing their toxicity towards normal cells.

Conclusion: In this review, we summarized the recent findings for different DDSs for various anti- cancer active complexes of some coinage metals.

Cite this article as:

Zhang Ming, Saint-Germain Camille, He Guiling and Sun Wai-Yin Raymond *, Drug Delivery Systems For Anti-Cancer Active Complexes of Some Coinage Metals, Current Medicinal Chemistry 2018; 25 (4) . https://dx.doi.org/10.2174/0929867324666170511152441