New Cyclohexylamine-dithiocarbamate Derivatives as Potential Anti-microbial Agents

Title:New Cyclohexylamine-dithiocarbamate Derivatives as Potential Anti-microbial Agents

Volume: 14 Issue: 11

Author(s): Leyla Yurttas*, Betul Kaya , Meral Yilmaz Cankilic and Serkan Levent

Affiliation:

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470,Turkey

Keywords: Dithiocarbamate, lipophilicity, antifungal activity, antibacterial activity, ADME, agents.

Abstract: Background: In this study, 2-(substituted-sulfanyl)-N,N-dicyclohexylacetamide derivatives (2a-2g) and 2-(dicyclohexylamino)-2-oxoethyl-1-substituted carbodithioate derivatives (2h-2m) were synthesized and screened for their antimicrobial activity.

Methods: Newly synthesized compounds were screened against two gram negative bacteria (S. typhimurium and E.coli), three gram positive bacteria (S. aureus, B. cereus and L. monocytogenes), four Candida species, four Aspergillus spp. and three Penicillium spp. Among them (2a-2m), compounds 2i (2-(dicyclohexylamino)-2-oxoethyl-thiomorpholine-4-carbodithioate) and 2k (2- (dicyclohexylamino)-2-oxoethyl-4-(4-methoxyphenyl)piperazine-1-carbodithioate) were detected to have higher inhibitory effect than other compounds.

Results and Conclusion: Minumum inhibitor concentrations (MICs) of the compounds were determined between the range of 97.5-390 µg/mL. Additionally, parameters determined that some physicochemical and toxic properties were predicted using computational methods.

Cite this article as:

Yurttas Leyla*, Kaya Betul, Cankilic Yilmaz Meral and Levent Serkan, New Cyclohexylamine-dithiocarbamate Derivatives as Potential Anti-microbial Agents, Letters in Drug Design & Discovery 2017; 14 (11) . https://dx.doi.org/10.2174/1570180814666170412121402