Abstract
Abstract: Background: Iron-sulfur clusters are inorganic prosthetic groups composed of only iron and inorganic sulfur atoms. Organisms develop different pathways to sense their local environment and to respond and adapt to changes.
Objective: We focused on Fe-S-containing proteins, which control their activity in response to redox signals by changing the redox state of their cluster. Result: When reduced, these Fe-S cluster-containing sensors are all inactive. As soon as their cluster perceives a signal that induces its oxidation, they switch to an « active state ». Conclusion: This sensing mechanism efficiently helps cells to turn on survival pathways quickly and recover from stressful conditions.Keywords: Fe-S cluster, sensor, redox state, cellular adaptive response, mitoNEET, iron.
Graphical Abstract
Related Journals
Current Bioactive Compounds
Combinatorial Chemistry & High Throughput Screening
Current Diabetes Reviews
Current Enzyme Inhibition
Current Molecular Medicine
Current Medicinal Chemistry
Current Topics in Medicinal Chemistry
Current Protein & Peptide Science
Medicinal Chemistry
Protein & Peptide Letters
Related Books
Aromatherapy: The Science of Essential Oils
Steroids and their Medicinal Potential
An Introduction to Mycosporine-Like Amino Acids
Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases
Mobile Computing Solutions for Healthcare Systems
Biopolymers Towards Green and Sustainable Development
Free Radical Biology of Endocrine, Metabolic & Immune Disorders
Biochemical Mechanisms of Aluminium Induced Neurological Disorders
Biochemistry: Fundamentals and Bioenergetics
Mind Maps in Clinical Chemistry (Part II)
48
2