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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update

Author(s): Sílvia Chaves, Luca Piemontese, Asha Hiremathad and M. Amélia Santos*

Volume 25, Issue 1, 2018

Page: [97 - 112] Pages: 16

DOI: 10.2174/0929867324666170330092304

Price: $65

Abstract

Hydroxypyridinones (HPs) are a family of N-heterocyclic metal chelators, which have been an attractive target in the development of a variety of new pharmaceutical drugs, due to their high metal chelating efficacy/specificity and easy derivatization to tune the desired biological properties. In fact, along the last decades, hydroxypyridinone derivatives, but mostly 3-hydroxy-4-pyridinone (3,4-HP), have been intensively used in drug design, following either a multitarget approach, in which one chelating unity is extrafunctionalized (hybridized) to enable the interaction with other important specific biological sites, or a polydenticity approach, in which more than one chelating moiety is conveniently attached to one scaffold, to increase the metal chelating efficacy. This review represents an update of the most recent publications (2014-2016) in mono-HP hybrids, namely as potential anti-Alzheimer's drugs, inhibitors of metalloenzymes and anti-microbials, and also polychelating compounds (poly- HP), in view of potential application, such as anti-microbial/biostatic agents, luminescent biosensors or diagnostic agents.

Keywords: Hydroxypyridinones, 3-hydroxy-4-pyridinones, iron chelators, anti-neurodegeneratives, bioinorganic medicinal chemistry.


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