Effects of Hyperlipidemia and Cardiovascular Diseases on Proliferation, Differentiation and Homing of Mesenchymal Stem Cells

Title:Effects of Hyperlipidemia and Cardiovascular Diseases on Proliferation, Differentiation and Homing of Mesenchymal Stem Cells

Volume: 12 Issue: 5

Author(s): Xin Ye and Chengfei Zhang *

Affiliation:

• Comprehensive Dental Care, Faculty of Dentistry, University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR,China

Keywords: Cardiovascular diseases, homing, hyperlipidemia, mesenchymal stem cells, osteogenic differentiation, proliferation.

Abstract: Background: Various clinical studies have revealed that cardiovascular diseases (CVD) are associated with bone loss diseases such as osteoporosis and periodontitis, especially in older population. As one of the best-established risk factors of CVD, hyperlipidemia is also reported to interfere with the metabolism, function and regeneration of mineralized tissues. Derived from postnatal tissue reservoirs, mesenchymal stem cells (MSCs) are considered promising cell sources for mesenchymal and non-mesenchymal tissue regeneration based on their capacities for self-renewal and multi-lineage differentiation as well as potent immunosuppressive effects, secretion of cytokines and regulation of vascularization. MSCs could home to the injury sites from peripheral circulation, proliferate and differentiate into bone-forming cells, therefore significantly enhancing bone regeneration. However, elevated blood lipid levels affect the physiological behaviors of MSCs, as well as the performance of transplanted MSCs.

Cite this article as:

Ye Xin and Zhang Chengfei*, Effects of Hyperlipidemia and Cardiovascular Diseases on Proliferation, Differentiation and Homing of Mesenchymal Stem Cells, Current Stem Cell Research & Therapy 2017; 12 (5) . https://dx.doi.org/10.2174/1574888X12666170316105805