p42.3 in Gastric Carcinoma: A Novel Biomarker and Promising Therapeutic Target

Title:p42.3 in Gastric Carcinoma: A Novel Biomarker and Promising Therapeutic Target

Volume: 14 Issue: 10

Author(s): Hui Jing, Lu-Lu Wei, Fu-Chun Huo, Xin Ren, Jun-Nian Zheng*Dong-Sheng Pei*

Affiliation:

• Department of pathology, Xuzhou Medical University, Xuzhou 221000, China, 209 Tongshan Road, Xuzhou, Jiangsu,China

• Department of pathology, Xuzhou Medical University, Xuzhou 221000, China, 209 Tongshan Road, Xuzhou, Jiangsu,China

Keywords: p42.3, gastric carcinoma, cell cycle, EMT, miR-29a, therapeutic target.

Abstract: Objective: To explore the function of p42.3 in gastric carcinoma.

Methods: We summarized the intricate regulation of p42.3 in gastric carcinoma from several aspects, namely, the structure features, the expression level, its regulation on cell cycle and EMT, its relationship with miR-29a as well as the optimal feedback circuit involved in.

Results: We addressed the complex functions of p42.3 in regulating EMT, migration, invasion, proliferation and the optimal regulation network in GC, as well as the significant up/down-stream signal molecules involved in the pathway. We have also illuminated that miR-29a can inhibit cell proliferation and block the cell cycle, at least in part, via the repression of p42.3.

Conclusion: In short, p42.3 might serve as a potential therapeutic target in the treatment of GC.

Cite this article as:

Jing Hui, Wei Lu-Lu , Huo Fu-Chun, Ren Xin , Zheng Jun-Nian *, Pei Dong-Sheng*, p42.3 in Gastric Carcinoma: A Novel Biomarker and Promising Therapeutic Target, Letters in Drug Design & Discovery 2017; 14 (10) . https://dx.doi.org/10.2174/1570180814666170306121357

DOI https://dx.doi.org/10.2174/1570180814666170306121357	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X