Abstract
Background: Asthma represents a worldwide health problem with a strong morbidity and a major impact on the health care system. Multiple efforts have been made towards the development of new strategies for the prevention and treatment of this disorder. In the light of this the present review of the literature aimed at summarizing the latest advances in prevention and treatment of pediatric asthma with a focus on the most effective options of interventions during the first stages of life.
Methods: References were identified by searches of PubMed. Search terms used in the search were “pediatric asthma”, “treatment” and “prevention”. We included only meta-analysis, randomized controlled trials, reviews and systematic review articles pertaining to humans and subjects aged 0-18 years. All the interventions have been classified as “non-pharmacological” and “pharmacological”.
Results: Non-pharmacological interventions have been focused in identifying the genetic and environmental factors underlying the pathogenesis of this disease, including the individual genetic susceptibility, the early allergic sensitization, the role of the environmental microbiome and the exposure to infections and to pollutants. Moreover, the optimization of the existing pharmacological strategies and the development of new treatment options have improved markedly the management of this disease, thereby reducing the health care costs and ameliorating the quality of life of patients.
Conclusion: Childhood asthma prevention and treatment still represents a worldwide challenge. Future efforts should be aimed at identifying high risk target populations, minimizing the costs of each policy of intervention and increasing adherence to treatment strategies.
Keywords: Allergic sensitization, antihistamines, antileukotrienes, asthma, childhood, corticosteroids, humanized monoclonal antibody, immunotherapy.
Current Medicinal Chemistry
Title:Update on Interventions in Prevention and Treatment of Pediatric Asthma
Volume: 25 Issue: 16
Author(s): Elisabetta Calamelli*, Paolo Bottau and Marcello Lanari
Affiliation:
- Pediatric and Neonatology Unit, Imola Hospital, Imola (BO),Italy
Keywords: Allergic sensitization, antihistamines, antileukotrienes, asthma, childhood, corticosteroids, humanized monoclonal antibody, immunotherapy.
Abstract: Background: Asthma represents a worldwide health problem with a strong morbidity and a major impact on the health care system. Multiple efforts have been made towards the development of new strategies for the prevention and treatment of this disorder. In the light of this the present review of the literature aimed at summarizing the latest advances in prevention and treatment of pediatric asthma with a focus on the most effective options of interventions during the first stages of life.
Methods: References were identified by searches of PubMed. Search terms used in the search were “pediatric asthma”, “treatment” and “prevention”. We included only meta-analysis, randomized controlled trials, reviews and systematic review articles pertaining to humans and subjects aged 0-18 years. All the interventions have been classified as “non-pharmacological” and “pharmacological”.
Results: Non-pharmacological interventions have been focused in identifying the genetic and environmental factors underlying the pathogenesis of this disease, including the individual genetic susceptibility, the early allergic sensitization, the role of the environmental microbiome and the exposure to infections and to pollutants. Moreover, the optimization of the existing pharmacological strategies and the development of new treatment options have improved markedly the management of this disease, thereby reducing the health care costs and ameliorating the quality of life of patients.
Conclusion: Childhood asthma prevention and treatment still represents a worldwide challenge. Future efforts should be aimed at identifying high risk target populations, minimizing the costs of each policy of intervention and increasing adherence to treatment strategies.
Export Options
About this article
Cite this article as:
Calamelli Elisabetta *, Bottau Paolo and Lanari Marcello , Update on Interventions in Prevention and Treatment of Pediatric Asthma, Current Medicinal Chemistry 2018; 25 (16) . https://dx.doi.org/10.2174/0929867324666170303162651
DOI https://dx.doi.org/10.2174/0929867324666170303162651 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Successful Desensitization of Three Patients with Hypersensitivity Reactions to Omalizumab
Current Drug Safety TLR2 and TLR4 Expression During Bacterial Infections
Current Pharmaceutical Design Recent Advancement and Technological Aspects of Pulsatile Drug Delivery System - A Laconic Review
Current Drug Targets Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance
CNS & Neurological Disorders - Drug Targets Role of Fibroblast Growth Factor 21 (FGF21) in the Regulation of Statural Growth
Current Pediatric Reviews The Menstrual Cycle and Drug Metabolism
Current Drug Metabolism Therapeutic Utility and Medicinal Chemistry of Cathepsin C Inhibitors
Current Topics in Medicinal Chemistry T Cell-based Therapies for Atherosclerosis
Current Pharmaceutical Design Recent Developments in the Medicinal Chemistry of NK2 Receptor Antagonists
Current Topics in Medicinal Chemistry Biodegradable Hydrogel Bead of Casein and Modified Xanthan Gum for Controlled Delivery of Theophylline
Current Drug Therapy The Yin and Yang of Non-Neuronal α7-Nicotinic Receptors in Inflammation and Autoimmunity
Current Drug Targets Risk Factors for Hyperemesis Gravidarum
Current Women`s Health Reviews Pandemic of Atopic Diseases - A Lack of Microbial Exposure in Early Infancy?
Current Drug Targets - Infectious Disorders Milestones in the Development of Chronic LPS-Induced Airway Disease
Current Respiratory Medicine Reviews Argemone mexicana: A Boon to Medicinal and Pharmacological Approaches in Current Scenario
Cardiovascular & Hematological Agents in Medicinal Chemistry Combination Therapeutic Approach for Asthma and Allergic Rhinitis
Current Clinical Pharmacology Thromboxane Synthase Inhibitors and Thromboxane A2 Receptor Antagonists: A Quantitative Structure Activity Relationships (QSARs) Analysis
Current Medicinal Chemistry Biomarkers in Asthma and COPD
Recent Patents on Biomarkers Toxicity of Carbon Nanotubes
Current Drug Metabolism The Role of the Methoxyphenol Apocynin, a Vascular NADPH Oxidase Inhibitor, as a Chemopreventative Agent in the Potential Treatment of Cardiovascular Diseases
Current Vascular Pharmacology