Abstract
Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the halflives of the species studied and/or detected increase considerably. In recent years, nitrones have been studied not only as free radical spin traps. Moreover, nitrones have been employed as therapeutic agents; in particular, those spin traps that are derived from α-phenyl-N-tert-butylnitrone (PBN). Nitrones as therapeutics agents have been used in the treatment of diseases related to oxidative stress such as neurodegeneration, cardiovascular disease and cancer.
Conclusion: In this review, we focus mainly on those studies where nitrones have been used as potential therapeutic agents in diseases such as cancer, neurodegenerative, acoustic trauma and others. In addition, we have shown that they continue to be a potent and important tool as radical spin trap as well as their use as therapeutic agent
Keywords: Nitrone, therapeutics, spin traps, cancer, neuroprotective, PBN, NXY-059.
Current Organic Chemistry
Title:Nitrones: A Potential New Alternative as Therapeutic Agents
Volume: 21 Issue: 20
Author(s): German Barriga-Gonzalez*, Carolina Aliaga, Claudio Olea-Azar, Maria C. Zuniga-Lopez, Mercedes Gonzalez and Hugo Cerecetto
Affiliation:
- Universidad de Santiago de Chile, Facultad de Quimica y Biologia, Departamento de Ciencias del Ambiente, Av. Libertador Bernardo O'Higgins 3363, Santiago,Chile
Keywords: Nitrone, therapeutics, spin traps, cancer, neuroprotective, PBN, NXY-059.
Abstract: Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the halflives of the species studied and/or detected increase considerably. In recent years, nitrones have been studied not only as free radical spin traps. Moreover, nitrones have been employed as therapeutic agents; in particular, those spin traps that are derived from α-phenyl-N-tert-butylnitrone (PBN). Nitrones as therapeutics agents have been used in the treatment of diseases related to oxidative stress such as neurodegeneration, cardiovascular disease and cancer.
Conclusion: In this review, we focus mainly on those studies where nitrones have been used as potential therapeutic agents in diseases such as cancer, neurodegenerative, acoustic trauma and others. In addition, we have shown that they continue to be a potent and important tool as radical spin trap as well as their use as therapeutic agent
Export Options
About this article
Cite this article as:
Barriga-Gonzalez German*, Aliaga Carolina, Olea-Azar Claudio, Zuniga-Lopez C. Maria, Gonzalez Mercedes and Cerecetto Hugo, Nitrones: A Potential New Alternative as Therapeutic Agents, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272821666170228131324
DOI https://dx.doi.org/10.2174/1385272821666170228131324 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Proteomic Analysis of Mitochondrial Proteins on the Mechanism of Apoptotic Under Amorphophallus konjac Tuber (KONJAC) Extracts in Gas tric Cancer Cell
Current Proteomics Voltage-Gated Ion Channels, New Targets in Anti-Cancer Research
Recent Patents on Anti-Cancer Drug Discovery Transforming Growth Factor-β: A Molecular Target for the Future Therapy of Glioblastoma
Current Pharmaceutical Design Neurosteroids and Hepatic Encephalopathy: An Update on Possible Pathophysiologic Mechanisms
Current Molecular Pharmacology Prognostic and Predictive Biomarkers in Colorectal Cancer. From the Preclinical Setting to Clinical Practice
Current Cancer Drug Targets Role of Cannabinoids and Endocannabinoids in Cerebral Ischemia
Current Pharmaceutical Design Oxazole-Based Compounds As Anticancer Agents
Current Medicinal Chemistry Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium Channels
Current Medicinal Chemistry Antiangiogenesis and Radiotherapy: What Is the Role of Combined Modality Treatment?
Current Medicinal Chemistry - Anti-Cancer Agents Anticancer Peptides and Proteins: A Panoramic View
Protein & Peptide Letters Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma
Anti-Cancer Agents in Medicinal Chemistry DYRK1A Kinase Inhibitors with Emphasis on Cancer
Mini-Reviews in Medicinal Chemistry Antineoplastic Potential of Medicinal Plants
Recent Patents on Biotechnology Targeted Liposomal Drug Delivery in Cancer
Current Pharmaceutical Design The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications
Current Genomics Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids
Current Topics in Medicinal Chemistry Dehydroleucodine Induces a TP73-dependent Transcriptional Regulation of Multiple Cell Death Target Genes in Human Glioblastoma Cells
Anti-Cancer Agents in Medicinal Chemistry Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery
Current Topics in Medicinal Chemistry Mesenchymal Stem Cells: New Approaches for the Treatment of Neurological Diseases
Current Stem Cell Research & Therapy Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
Current Cancer Drug Targets