Background: Ageing is a natural phenomenon that has tremendous amount of control
over normal physiological functions. Diabetes mellitus and ageing share common symptoms like
stiffness and loss of functioning of tissues due to cross-liked proteins and free radicals. Glycated
Haemoglobin (HbA1c) is often used as a stable cumulative index of glycemic control and has shown
that even in non-diabetic adults, there is a steady increase in HbA1c levels with age.
Aim of the study is to evaluate the strength of association of HbA1c with metabolic and cardiovascular
ageing indices in subjects between the age group of 40 to 60 yrs.
Method: A total of 220 subjects, with (n=110) and without (n=110) diabetes were assessed for the
metabolic and cardiovascular ageing indices. BMI, waist hip ratio, fat percentage, Fasting blood
sugar and HbA1c were assessed as metabolic ageing indices. The cardiovascular ageing indices
measured were resting heart rate, blood pressure and heart rate variability.
Results: Ageing indices were compared between subjects with and without diabetes using independent‘
t’ test and showed that the T2DM group exhibit significant accelerated ageing as compared
to that of the controls. Pearson’s and partial correlation coefficient was used to assess the association
of HbA1c with the ageing indices without and with controlling for chronological age, indicated that,
strength of association of levels of HBA1c with cardiovascular and other metabolic indices of ageing
is statistically significant.
Conclusion: The study concludes that the tightness of glycemic control has a significant impact on
the biological ageing process