Introduction: Diabetic nephropathy is characterized by hypertension, progressive albuminuria,
glomerulosclerosis and declines in glomerular filtration rate leading to end stage renal disease.
Although the pathogenesis of diabetic nephropathy is not fully understood, current treatment of the patients
with diabetic nephropathy is mainly based upon the control of hyperglycaemia and management
of blood pressures.
Background: Several drugs, which are originally developed for hypertension therapy, have been
adopted for stabilization of renal function in diabetic nephropathy. In this review, we first discussed
the relationships between diabetic nephropathy and hypertension particularly in the renin-angiotensinaldosterone
system. We then summarized chemical structures, pharmacological characteristics and
clinical studies of the common drugs used for treatment of diabetic nephropathy, while these drugs
have effects against hypertension.
Conclusion: This review may provide the constructive information for further drug development in