Abstract
Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.
Keywords: Aggregation, formulation, storage, delivery, insulin, glucagon, antibodies
Protein & Peptide Letters
Title:When Good Goes Awry: The Aggregation of Protein Therapeutics
Volume: 24 Issue: 4
Author(s): Jennifer M. Redington, Leonid Breydo and Vladimir N. Uversky
Affiliation:
Keywords: Aggregation, formulation, storage, delivery, insulin, glucagon, antibodies
Abstract: Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.
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Cite this article as:
Redington M. Jennifer , Breydo Leonid and Uversky N. Vladimir , When Good Goes Awry: The Aggregation of Protein Therapeutics, Protein & Peptide Letters 2017; 24 (4) . https://dx.doi.org/10.2174/0929866524666170209153421
DOI https://dx.doi.org/10.2174/0929866524666170209153421 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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