Phoenixin: A Newly Discovered Peptide with Multi-Functions

Title:Phoenixin: A Newly Discovered Peptide with Multi-Functions

Volume: 24 Issue: 6

Author(s): Taoyan Yuan, Zhongxin Sun, Wanqiu Zhao, Tao Wang, Jufang Zhang*Dong Niu*

Affiliation:

• Cosmetic & Plastic Surgery Department, Hangzhou First People’s Hospital, 261 Huansha Road, Hangzhou 310006,China

• College of Animal Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058,China

Keywords: Phoenixin, C4orf52, GnRH, Gpr173, reproductive peptide, cognate receptor.

Abstract: Phoenixin (PNX), a newly identified peptide cleaved from the C-terminus of protein C4orf52, mainly exists in two active isoforms, phoenixin-14 (PNX-14) amide and phoenixin-20 (PNX-20) amide that were first isolated from the rat hypothalamus and bovine heart, respectively. Initial studies demonstrated that PNX is a reproductive peptide, which affects the hypothalamus pituitary genital (HPG) axis through regulating the expression of kisspeptin, GnRH, GnRH receptor, LH and oestrus process. However, further studies indicated that PNX might play a wide range of roles in additional physiological process such as inhibiting visceral pain and eliciting pruritus, inducing anxiety, improving memory retention. Recently, Gpr173, also designated as SREB3, was identified as the cognate receptor of PNX. Whereas, the regulatory mechanism of PNX has not been fully clarified. This review aims to provide the current knowledge of PNX and propose some study directions for future research.

Cite this article as:

Yuan Taoyan, Sun Zhongxin, Zhao Wanqiu, Wang Tao, Zhang Jufang*, Niu Dong*, Phoenixin: A Newly Discovered Peptide with Multi-Functions, Protein & Peptide Letters 2017; 24 (6) . https://dx.doi.org/10.2174/0929866524666170207154417