Abstract
Background & Objective: The emergence of multidrug-resistant virus, bacteria and fungi has created an urgent need for the development of novel antibiotic drugs from natural products with different mechanism of action. Therefore, in this review, seventeen types of isoquinoline alkaloids, including benzyltetrahydroisoquinoline, benzylisoquinoline, bisbenzylisoquinoline, aporphine, tetrahydroprotoberberine, N-methyltetrahydroprotoberberine, protoberberine, protopine, benzophenanthridine, dihydrobenzophenanthridine, pavine, cularine, phthalideiso-quinoline, spirobenzylisoquinoline, promorphine, morphine and ipecac, were screened and regarded as an attractive target for the discovery of new antiviral, antibacterial and antifungal lead compounds or agents.
Method: Notably, sixteen types of alkaloids were biosynthesized from the central precursor benzyltetrahydroisoquinoline in herbal medicine. Finally, the antiviral and antimicrobial activities of 210 isoquinoline alkaloids were uncovered and the structure-activity relationships were also summarized.
Conclusion: The quaternary nitrogen and the methylenedioxy at C-2 and C-3 played an important role in increasing the antiviral, antibacterial and antifungal activity of N-methyltetrahydroprotoberberine, protoberberine and benzophenanthridine alkaloids.
Keywords: Isoquinoline alkaloids, antiviral, antibacterial, antifungal, antimicrobial, structure-activity relationship, HIV.
Current Organic Chemistry
Title:Isoquinoline Alkaloids and Their Antiviral, Antibacterial, and Antifungal Activities and Structure-activity Relationship
Volume: 21 Issue: 18
Author(s): Zhi-Xing Qing, Peng Yang, Qi Tang, Pi Cheng, Xiu-Bin Liu, Ya-jie Zheng, Yi-Song Liu*Jian-Guo Zeng*
Affiliation:
- Department of Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128,China
- Department of Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128,China
Keywords: Isoquinoline alkaloids, antiviral, antibacterial, antifungal, antimicrobial, structure-activity relationship, HIV.
Abstract: Background & Objective: The emergence of multidrug-resistant virus, bacteria and fungi has created an urgent need for the development of novel antibiotic drugs from natural products with different mechanism of action. Therefore, in this review, seventeen types of isoquinoline alkaloids, including benzyltetrahydroisoquinoline, benzylisoquinoline, bisbenzylisoquinoline, aporphine, tetrahydroprotoberberine, N-methyltetrahydroprotoberberine, protoberberine, protopine, benzophenanthridine, dihydrobenzophenanthridine, pavine, cularine, phthalideiso-quinoline, spirobenzylisoquinoline, promorphine, morphine and ipecac, were screened and regarded as an attractive target for the discovery of new antiviral, antibacterial and antifungal lead compounds or agents.
Method: Notably, sixteen types of alkaloids were biosynthesized from the central precursor benzyltetrahydroisoquinoline in herbal medicine. Finally, the antiviral and antimicrobial activities of 210 isoquinoline alkaloids were uncovered and the structure-activity relationships were also summarized.
Conclusion: The quaternary nitrogen and the methylenedioxy at C-2 and C-3 played an important role in increasing the antiviral, antibacterial and antifungal activity of N-methyltetrahydroprotoberberine, protoberberine and benzophenanthridine alkaloids.
Export Options
About this article
Cite this article as:
Qing Zhi-Xing, Yang Peng , Tang Qi , Cheng Pi , Liu Xiu-Bin , Zheng Ya-jie , Liu Yi-Song*, Zeng Jian-Guo*, Isoquinoline Alkaloids and Their Antiviral, Antibacterial, and Antifungal Activities and Structure-activity Relationship, Current Organic Chemistry 2017; 21 (18) . https://dx.doi.org/10.2174/1385272821666170207114214
DOI https://dx.doi.org/10.2174/1385272821666170207114214 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Etiopathogenesis, Classical Immunotherapy and Innovative Nanotherapeutics for Inflammatory Neurological Disorders
Current Nanoscience Neuroimmunomodulation and Aging: A Role for Transferrin and the Hypothalamus/Thymus Axis
Current Aging Science Circulating MicroRNAs as Biomarkers for Inflammatory Diseases
MicroRNA Editorial (Special Board Members Issue)
Protein & Peptide Letters Management of Adult Active Tuberculosis Disease in Era of HIV Pandemic, Current Practices and Future Perspectives
Infectious Disorders - Drug Targets Adhatoda vasica Nees: Phytochemical and Pharmacological Profile
The Natural Products Journal Eight Stranded β -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis
Protein & Peptide Letters Inflammatory Caspases: Targets for Novel Therapies
Current Pharmaceutical Design Intelligently Applying Artificial Intelligence in Chemoinformatics
Current Topics in Medicinal Chemistry Substance P at the Neuro-Immune Crosstalk in the Modulation of Inflammation, Asthma and Antimicrobial Host Defense
Inflammation & Allergy - Drug Targets (Discontinued) MenA Is a Promising Drug Target for Developing Novel Lead Molecules to Combat Mycobacterium tuberculosis
Medicinal Chemistry Updated Acute Community-Acquired Pneumonia in Adults: Guidelines for Initial Antimicrobial Therapy Based on Local Evidence from the South American Working Group (Consensur II)
Current Respiratory Medicine Reviews DC-SIGN Antagonists, a Potential New Class of Anti-Infectives
Current Medicinal Chemistry Methods to Measure Target Site Penetration of Antibiotics in Critically Ill Patients
Current Clinical Pharmacology Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review
Current Drug Safety Antibacterial Activity and Structure-activity Relationship Studies of 4- substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones
Letters in Drug Design & Discovery Non-Antidepressant Treatment of Social Anxiety Disorder: A Review
Current Clinical Pharmacology Lipid Matrix Nanoparticles: Pharmacokinetics and Biopharmaceutics
Current Nanoscience Recent Patents on Proteases and Kinases as Anti-Infective Agents: A Review
Recent Patents on Anti-Infective Drug Discovery Computational Sampling and Simulation Based Assessment of Novel <i>Mycobacterium tuberculosis</i> Glutamine Synthetase Inhibitors: Study Involving Structure Based Drug Design and Free Energy Perturbation
Current Topics in Medicinal Chemistry