Abstract
Background: Tin-promoted allylation of carbonyl or imino groups is one of the most convenient and efficient methods for synthesis of homoallylic compounds, which are versatile building blocks in the preparation of many biologically active molecules and natural products.
Objective: This review provides an insight into one-pot allylation reactions for the synthesis of different homoallylic compounds promoted by tin powder.
Conclusion: In the last four decades, tin powder-promoted allylation process has been exploited in synthesis of homoallylic compounds. This multicomponent “one-pot” strategy avoids a lengthy separation process and purification of the intermediate chemical compounds, which saves time and resources while increasing the chemical yield. This tin-promoted process has the following features: operational simplicity, good tolerance to functional groups and improved yields. The protocol could be carried out under wet conditions or even in pure water.
Keywords: Tin powder, One-Pot, allylation reaction, allylic bromide, homoallylic alcohol, homoallylic amines.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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