Abstract
Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.
Keywords: Sumoylation, neurological diseases, neuronal function, synapse formation.
Current Molecular Medicine
Title:SUMOylation in Neurological Diseases
Volume: 16 Issue: 10
Author(s): F.-Y. Liu, Y.-F. Liu, Y. Yang, Z.-W. Luo, J.-W. Xiang, Z.-G. Chen, R.-L. Qi, T.-H. Yang, Y. Xiao, W.-J. Qing and D. W.-C. Li
Affiliation:
Keywords: Sumoylation, neurological diseases, neuronal function, synapse formation.
Abstract: Since the discovery of SUMOs (small ubiquitin-like modifiers) over 20 years ago, sumoylation has recently emerged as an important posttranslational modification involved in almost all aspects of cellular physiology. In neurons, sumoylation dynamically modulates protein function and consequently plays an important role in neuronal maturation, synapse formation and plasticity. Thus, the dysfunction of sumoylation pathway is associated with many different neurological disorders. Hundreds of different proteins implicated in the pathogenesis of neurological disorders are SUMO-modified, indicating the importance of sumoylation involved in the neurological diseases. In this review, we summarize the growing findings on protein sumoylation in neuronal function and dysfunction. It is essential to have a thorough understanding on the mechanism how sumoylation contributes to neurological diseases in developing efficient therapy for these diseases.
Export Options
About this article
Cite this article as:
Liu F.-Y., Liu Y.-F., Yang Y., Luo Z.-W., Xiang J.-W., Chen Z.-G., Qi R.-L., Yang T.-H., Xiao Y., Qing W.-J. and Li W.-C. D., SUMOylation in Neurological Diseases, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524017666170109125256
DOI https://dx.doi.org/10.2174/1566524017666170109125256 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems
Current Drug Targets The Cytokine Network in HIV Infection
Current Molecular Medicine NF-κB, a Potential Therapeutic Target for the Treatment of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Pathology of Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Cyclosporin and Organ Specific Toxicity: Clinical Aspects, Pharmacogenetics and Perspectives
Current Clinical Pharmacology Ideational Fluency in Patients with Rheumatoid Arthritis
Current Rheumatology Reviews The Changing Face of HIV/AIDS in Treated Patients
Current HIV Research Design, Sar, and Metabolism Study of Crucifereae Family Compound (Spirobrassinin) and its Analogs for Antiangiogenic Potential Targeting Hsp90
Current Proteomics Molecular Targets of Rheumatoid Arthritis
Inflammation & Allergy - Drug Targets (Discontinued) “Vascular Incontinence” and Normal-Pressure Hydrocephalus: Two Commonsources of Elderly Incontinence with Brain Etiologies
Current Drug Therapy Current and Future Therapies Targeting the Immune System in Multiple Sclerosis
Current Pharmaceutical Biotechnology Advances in the Management of Brain Tumors in Infants
Current Cancer Therapy Reviews Azathioprine in Multiple Sclerosis
Mini-Reviews in Medicinal Chemistry Acute Ischemic Cerebrovascular Events on Antiplatelet Therapy: What is the Optimal Prevention Strategy?
Current Pharmaceutical Design Silencing the Brain May be Better than Stimulating it. The GABA Effect
Current Pharmaceutical Design Matrix Metalloproteinases as Potential Targets in the Venous Dilation Associated with Varicose Veins
Current Drug Targets An Update of the Review of Neuropsychological Consequences of HIV and Substance Abuse: A Literature Review and Implications for Treatment and Future Research
Current Drug Abuse Reviews Interplay between Catalysts and Substrates for Activity of Class Ib Aminoacyl-tRNA Synthetases and Implications for Pharmacology
Current Topics in Medicinal Chemistry Opiate Drug Use and the Pathophysiology of NeuroAIDS
Current HIV Research Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective
Current Rheumatology Reviews