Abstract
Among the clinical spectrum of neurological diseases, migraine is often associated with cerebro-vasculopathy. Impairment of neuroimmune mediators in the central nervous system has been recognized in the pathophysiology of migraine-related stroke. Although genetic correlation was found in patients with migraine-related stroke, the epidemiology of this disease indicates a need in biomarker searching discovery and validation. In this view, small molecule, called microRNAs (miRNAs), able to regulate immune and neuronal processes has been reported in patients with migraine and ischemic stroke and unambiguous miRNAs related to these diseases could be established as new molecular indicator of precocity for clinical and/or pharmacological intervention. Therefore, further exploration of this area is necessary, as greater understanding of these biomarkers could reveal the common mechanisms involved in the pathophysiology of migraine in patients with cerebral infarct.
Keywords: Cerebral infarct, cerebrovascular diseases, microRNA, migraine, neurological diseases, pathophysiology.
MicroRNA
Title:microRNAs-based Predictor Factor in Patients with Migraine-ischemic Stroke
Volume: 6 Issue: 1
Author(s): Luca Gallelli, Antonio Siniscalchi*, Marco Carotenuto, Maria C. Caroleo, Erika Cione and Vincenzo Guidetti
Affiliation:
- Department of Neurology, Annunziata Hospital Via F. Migliori, 1; 87100 Cosenza,Italy
Keywords: Cerebral infarct, cerebrovascular diseases, microRNA, migraine, neurological diseases, pathophysiology.
Abstract: Among the clinical spectrum of neurological diseases, migraine is often associated with cerebro-vasculopathy. Impairment of neuroimmune mediators in the central nervous system has been recognized in the pathophysiology of migraine-related stroke. Although genetic correlation was found in patients with migraine-related stroke, the epidemiology of this disease indicates a need in biomarker searching discovery and validation. In this view, small molecule, called microRNAs (miRNAs), able to regulate immune and neuronal processes has been reported in patients with migraine and ischemic stroke and unambiguous miRNAs related to these diseases could be established as new molecular indicator of precocity for clinical and/or pharmacological intervention. Therefore, further exploration of this area is necessary, as greater understanding of these biomarkers could reveal the common mechanisms involved in the pathophysiology of migraine in patients with cerebral infarct.
Export Options
About this article
Cite this article as:
Gallelli Luca, Siniscalchi Antonio*, Carotenuto Marco, Caroleo C. Maria, Cione Erika and Guidetti Vincenzo, microRNAs-based Predictor Factor in Patients with Migraine-ischemic Stroke, MicroRNA 2017; 6 (1) . https://dx.doi.org/10.2174/2211536606666170104130101
DOI https://dx.doi.org/10.2174/2211536606666170104130101 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Analysis of Adverse Events Related to 720 Cases of Neural Progenitor Cell Transplantation
CNS & Neurological Disorders - Drug Targets Treating Cancer and No-Cancer Pain in Older and Oldest Old Patients
Current Pharmaceutical Design Emerging Drugs and Indications for Cardio-Metabolic Disorders in People with Severe Mental Illness
Current Pharmaceutical Design Non Smoking for Successful Aging: Therapeutic Perspectives
Current Pharmaceutical Design Monoclonal Antibodies: A New Era in the Treatment of Non-Hodgkins Lymphoma
Current Pharmaceutical Biotechnology A Neuroinformatics Study Describing Molecular Interaction of Cisplatin with Acetylcholinesterase: A Plausible Cause for Anticancer Drug Induced Neurotoxicity
CNS & Neurological Disorders - Drug Targets Is There Any Scientific Basis of Hawan to be Used in the Alzheimer’s Disease Prevention/Cure?
Current Traditional Medicine Biochemical Markers of Autoimmune Diseases of the Nervous System
Current Pharmaceutical Design Understanding the Use of Immunosuppressive Agents in the Clinical Management of IBD
Current Drug Targets Emerging Evidence for the Role of Neurotransmitters in the Modulation of T Cell Responses to Cognate Ligands
Central Nervous System Agents in Medicinal Chemistry Serotonin Transporter Gene Variants and Behavior: A Comprehensive Review
Current Drug Targets Effect of Probenecid on the Pain-Related Behaviour and Morphological Markers in Orofacial Formalin Test of the Rat
CNS & Neurological Disorders - Drug Targets Chronic Kidney Disease and Sleeping Disordered Breathing (SDB)
Current Hypertension Reviews Pneumonia Due to Methicilin-Resistant Staphylococcus aureus (MRSA): A Review
Current Respiratory Medicine Reviews Mitochondrial Disturbances, Tryptophan Metabolites and Neurodegeneration: Medicinal Chemistry Aspects
Current Medicinal Chemistry Caffeine; the Forgotten Potential for Parkinson's Disease
CNS & Neurological Disorders - Drug Targets Natural Medicine:The Genus Angelica
Current Medicinal Chemistry Treating Benign Prostatic Hyperplasia with Botulinum Neurotoxin
Current Medicinal Chemistry Mental Health Services for Minor Detainees at Guantanamo
Adolescent Psychiatry Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial
CNS & Neurological Disorders - Drug Targets