Abstract
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the commonest skin malignancies and if diagnosed early have a good prognosis. Conversely, metastatic disease is rarely associated with a very poor prognosis. Locally advanced BCC is also uncommon and may not be amendable to surgery, radiation therapy or photodynamic therapy. The activation of the hedgehog pathway occurs in 90% of BCCs and inhibition of this pathway with well tolerated oral agents has resulted in an important therapeutic option in some patients with locally advanced or metastatic BCC. In contrast, metastatic SCC tends to behave biologically more aggressively and cisplatin based chemotherapy has very limited efficacy.
Keywords: Chemotherapy, targeted therapy, basal cell carcinoma, squamous cell carcinoma, nonmelanoma.
Current Cancer Therapy Reviews
Title:Chemotherapy and Molecular Therapy in Non-Melanoma Skin Cancer
Volume: 12 Issue: 3
Author(s): Vamsee Torri
Affiliation:
Keywords: Chemotherapy, targeted therapy, basal cell carcinoma, squamous cell carcinoma, nonmelanoma.
Abstract: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the commonest skin malignancies and if diagnosed early have a good prognosis. Conversely, metastatic disease is rarely associated with a very poor prognosis. Locally advanced BCC is also uncommon and may not be amendable to surgery, radiation therapy or photodynamic therapy. The activation of the hedgehog pathway occurs in 90% of BCCs and inhibition of this pathway with well tolerated oral agents has resulted in an important therapeutic option in some patients with locally advanced or metastatic BCC. In contrast, metastatic SCC tends to behave biologically more aggressively and cisplatin based chemotherapy has very limited efficacy.
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Cite this article as:
Torri Vamsee, Chemotherapy and Molecular Therapy in Non-Melanoma Skin Cancer, Current Cancer Therapy Reviews 2016; 12 (3) . https://dx.doi.org/10.2174/1573394713666161229124633
DOI https://dx.doi.org/10.2174/1573394713666161229124633 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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