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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Review Article

Sumoylation in Cellular Senescence and Aging

Author(s): L. Gong, Q. Sun and D. W.-C. Li

Volume 16, Issue 10, 2016

Page: [871 - 876] Pages: 6

DOI: 10.2174/1566524016666161223104915

Price: $65

Abstract

Sumoylation is a reversible post-translational modification that conjugates small peptide SUMO (small ubiquitin-like modifier) to a target protein. Global protein sumoylation and expression of components in sumoylation pathway were recently found to be altered in the process of organismal aging. In addition, key factors controlling cellular senescence are known to be sumoylated. This review will summarize current information on the function of sumoylation in cellular senescence and aging.

Keywords: Sumoylation, p53, RB, senescence, aging.


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