Title:The Potential of Nano-Vehicle Mediated Therapy in Vasculitis and Multiple Sclerosis
VOLUME: 23 ISSUE: 13
Author(s):R. Huis In ’t Veld, C.G. Da Silva, E.L. Kaijzel, A.B. Chan and L.J. Cruz*
Affiliation:Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Center, Leiden, Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Center, Leiden, Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Center, Leiden, Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Center, Leiden, Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Center, Leiden
Keywords:Nano-vehicle, nanoparticle, vasculitis, multiple sclerosis, drug delivery, targeting, drug release, immune suppressive drugs,
nanomedicine, glucocorticosteroids.
Abstract:The induction of immune tolerance towards self-antigens presents as a viable future strategy in the
treatment of auto-immune diseases, including vasculitis and multiple sclerosis (MS). As specific targets are currently
lacking for vasculitis due to incomplete understanding of the pathologies underlying this disease, current
treatment options are based on modalities that induce general immune suppression. However, many immune
suppressants used in the clinic are known to display wide biodistribution and are thus often accompanied by several
adverse effects. Nano-vehicles (NVs) possess the ability to overcome such limitations by enabling more
specific delivery of their content through modifications with targeting moieties. In this review, we describe the
latest insights in the pathology of vasculitis that may function as potential targets for NV carrier systems, allowing
more specific delivery of currently used immune suppressants. In addition, we describe the existing strategies
to induce artificial immune tolerance and explore the feasibility of inducing regulatory T cell (Treg) mediated
tolerance for MS, possibly mediated by NVs.
