Prediction of Chemical Multi-target Profiles and Adverse Outcomes with Systems Toxicology

Title:Prediction of Chemical Multi-target Profiles and Adverse Outcomes with Systems Toxicology

Volume: 24 Issue: 16

Author(s): Henri Wathieu, Abiola Ojo and Sivanesan Dakshanamurthy*

Affiliation:

• Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC, 20057,United States

Keywords: Adverse outcome pathway, adverse reactions, biological network models, computational toxicology, drug development, environmental toxicology, multi-target compounds, network analysis, systems toxicology.

Abstract: The field of systems biology, termed systems toxicology when applied to the characterization of adverse outcomes following chemical exposure, seeks to develop biological networks to explain phenotypic responses. Ideally, these are qualitatively and quantitatively similar to the actual network of biological entities that have functional consequences in living organisms. In this review, computational tools for predicting chemicalprotein interactions of multi-target compounds are outlined. Then, we discuss how the methods of systems toxicology currently draw on those interactions to predict resulting adverse outcomes which include diseases, adverse drug reactions, and toxic endpoints. These methods are useful for predicting the safety of drugs in drug development and the toxicity of environmental chemicals (ECs) in environmental toxicology.

Cite this article as:

Wathieu Henri, Ojo Abiola and Dakshanamurthy Sivanesan*, Prediction of Chemical Multi-target Profiles and Adverse Outcomes with Systems Toxicology, Current Medicinal Chemistry 2017; 24 (16) . https://dx.doi.org/10.2174/0929867323666161214115540