Abstract
Background: RGD peptides are small peptides containing arginine-glycine-aspartic (Arg- Gly-Asp) acid triple-peptide motif and can specifically bind to integrin receptor on the cell surface.
Discussion: The integrin receptors, especially alpha(v) beta(3), are highly expressed on the surface of activated endothelial cells and tumor cells while displaying low expression on mature endothelial cells. Molecular imaging can achieve the imaging of the biological processes at cellular and molecular levels in vivo and help in qualitative and quantitative research, making the evaluation of the expression levels of integrin possible in vivo.
Conclusion: Therefore, RGD peptides show great potential in the study of specific imaging of tumor- induced angiogenesis. This study reviewed the recent research progress of RGD peptide– mediated imaging of tumor-induced angiogenesis, which can benefit the RGD peptide–targeted molecular imaging researches.
Keywords: Integrin, molecular probe, RGD peptide, targeted MRI, angiogenesis, endothelial cells.
Graphical Abstract
Call for Papers in Thematic Issues
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