Abstract
Introduction: Fourteen novel 8,8-dimethyl-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)- one derivatives were rationally designed and synthesized successfully. The synthetic procedures adopted for the target molecules were achieved by facile protocols and the yields were good to excellent (> 80%).
Method: All the synthesized compounds were characterized by 1H NMR, 13C NMR, HR-MS and FT-IR spectral analysis. All new compounds were evaluated for their in vitro antioxidant activity by using DPPH, ABTS, NO and H2O2 methods. Results: Among the novel derivatives, two of the synthesized compounds exhibited good antioxidant activities similar to ascorbic acid, in all the four tested methods.Keywords: Pyrimidines, synthesis, anti-oxidant activity, simple method, in vitro studies, human body.
Letters in Drug Design & Discovery
Title:Novel Chromeno[2,3-d]pyrimidines-Design, Synthesis and Antioxidant Activity
Volume: 14 Issue: 7
Author(s): Kotiah Yalagala, Sreekantha B. Jonnalagadda*, Suresh Maddila, Surjyakanta Rana and Surya Narayana Maddila
Affiliation:
- School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban-4000,south africa
Keywords: Pyrimidines, synthesis, anti-oxidant activity, simple method, in vitro studies, human body.
Abstract: Introduction: Fourteen novel 8,8-dimethyl-8,9-dihydro-5H-chromeno[2,3-d]pyrimidin-6(7H)- one derivatives were rationally designed and synthesized successfully. The synthetic procedures adopted for the target molecules were achieved by facile protocols and the yields were good to excellent (> 80%).
Method: All the synthesized compounds were characterized by 1H NMR, 13C NMR, HR-MS and FT-IR spectral analysis. All new compounds were evaluated for their in vitro antioxidant activity by using DPPH, ABTS, NO and H2O2 methods. Results: Among the novel derivatives, two of the synthesized compounds exhibited good antioxidant activities similar to ascorbic acid, in all the four tested methods.Export Options
About this article
Cite this article as:
Yalagala Kotiah, Jonnalagadda B. Sreekantha*, Maddila Suresh, Rana Surjyakanta and Maddila Narayana Surya, Novel Chromeno[2,3-d]pyrimidines-Design, Synthesis and Antioxidant Activity, Letters in Drug Design & Discovery 2017; 14 (7) . https://dx.doi.org/10.2174/1570180814666161123143637
DOI https://dx.doi.org/10.2174/1570180814666161123143637 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The In Silico Prediction of Human-Specific Metabolites from Hepatotoxic Drugs
Current Drug Discovery Technologies Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model
Anti-Cancer Agents in Medicinal Chemistry Synthesis of Some Novel 2-Azetidinones/4-Thiazolidinones Bearing 1, 3, 4- Thiadiazole Nucleus and Screening for its Anti-Imflammatory Activity
Letters in Drug Design & Discovery Flexible Structures and Ligand Interactions of Tandem Repeats Consisting of Proline, Glycine, Asparagine, Serine, and/or Threonine Rich Oligopeptides in Proteins
Current Protein & Peptide Science Novel Options for the Pharmacological Treatment of Chronic Anal Fissure – Role of Botulin Toxin
Current Clinical Pharmacology The Role of PPARβ/δ in the Management of Metabolic Syndrome and its Associated Cardiovascular Complications
Endocrine, Metabolic & Immune Disorders - Drug Targets Synthesis of Monosulfated Lewis a Trisaccharide Library Through Sulfation of a Partial Protected Trisaccharide
Letters in Organic Chemistry Recent Advances on Liquid Chromatographic and Mass Spectrometric Analysis of Selective Estrogen Receptor Modulators (SERMs) in Biological Fluids
Current Chromatography Virtual Screening of Natural Products to Select Compounds with Potential Anticancer Activity
Anti-Cancer Agents in Medicinal Chemistry Resveratrol as an Enhancer of Apoptosis in Cancer: A Mechanistic Review
Anti-Cancer Agents in Medicinal Chemistry Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs
Current Nanoscience Combining In Silico Protein Stability Calculations with Structure-Function Relationships to Explore the Effect of Polymorphic Variation on Cytochrome P450 Drug Metabolism
Current Drug Metabolism The Design of Vectors for RNAi Delivery System
Current Pharmaceutical Design Expanding the Therapeutic Potential of Statins by Means of Nanotechnology Enabled Drug Delivery Systems
Current Topics in Medicinal Chemistry Strategies of Development of Antiviral Agents Directed Against Influenza Virus Replication
Current Pharmaceutical Design Immune Regulation by the Posttranslational Modification O-GlcNAc
Current Signal Transduction Therapy Proteomics Can Help to Gain Insights into Metabolic Disorders According to Body Reserve Availability
Current Medicinal Chemistry Metabolomic Biomarkers in Gynecology: A Treasure Path or a False Path?
Current Medicinal Chemistry In Silico Analysis of Amino Acid Sequences in Relation to Specificity and Physiochemical Properties of Mesophilic and Thermophilic Antileukemic L-Asparaginases
Current Biotechnology On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action
Current Pharmaceutical Biotechnology