Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes

Title:Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes

Volume: 24 Issue: 4

Author(s): George A. Stravodimos, Ben A. Chetter, Efthimios Kyriakis, Anastassia L. Kantsadi, Demetra S.M. Chatzileontiadou, Vassiliki T. Skamnaki, Atsushi Kato, Joseph M. Hayes and Demetres D. Leonidas

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Keywords: Alpha-glucosidases, antioxidants, diabetes, glycogen phosphorylase, flavonoids, pentacyclic triterpenes.

Abstract: Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors of GP. These compounds have both pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review focuses mainly on the most successful (potent) of these compounds discovered to date. The protein-ligand interactions that form the structural basis of their potencies are discussed, highlighting the potential for exploitation of their scaffolds in the future design of new GP inhibitors.

Cite this article as:

Stravodimos A. George, Chetter A. Ben, Kyriakis Efthimios, Kantsadi L. Anastassia, Chatzileontiadou S.M. Demetra, Skamnaki T. Vassiliki, Kato Atsushi, Hayes M. Joseph and Leonidas D. Demetres, Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes, Current Medicinal Chemistry 2017; 24 (4) . https://dx.doi.org/10.2174/0929867324666161118122534