Abstract
Response to drug administration is a primary determinant for treatment success. Sex and gender disparities play a role in determining the efficacy and safety of the most commonly used medications suggesting the need for a sex-tailored approach in prescription. Statins are a cost-effective strategy for cardiovascular disease (CVD) prevention. While statins are similarly effective in secondary CVD prevention, some concerns raised by conflicting data reported in primary CVD prevention clinical trials. The small representation of women in clinical trials and the fewer rates of events due to the lower female baseline CVD risk may have conditioned contradictory meta-analysis findings. Specifically, benefits outweigh disadvantages of statin therapy in women with a high CVD risk, while several doubts exist for the primary prevention of women at low-intermediate CVD risk. Furthermore, disparities between women and men in medication adherence may influence statin efficacy in CVD prevention. The sex-dependent impact of adverse side effects is one of the reasons advocated for explaining the gender gap, but it is not evidence-proved.
The present review summarizes the sex and gender differences in the use of statins, pointing out new perspectives and opening issues in sex-tailored CVD prevention strategy.Keywords: Statin, cardiovascular disease, prevention, medication adherence, sex, gender.
Current Medicinal Chemistry
Title:Treatment and Response to Statins: Gender-related Differences
Volume: 24 Issue: 24
Author(s): Valeria Raparelli, Gaetano Pannitteri, Tommaso Todisco , Filippo Toriello, Laura Napoleone , Roberto Manfredini and Stefania Basili*
Affiliation:
- Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, 00144 Rome,Italy
Keywords: Statin, cardiovascular disease, prevention, medication adherence, sex, gender.
Abstract: Response to drug administration is a primary determinant for treatment success. Sex and gender disparities play a role in determining the efficacy and safety of the most commonly used medications suggesting the need for a sex-tailored approach in prescription. Statins are a cost-effective strategy for cardiovascular disease (CVD) prevention. While statins are similarly effective in secondary CVD prevention, some concerns raised by conflicting data reported in primary CVD prevention clinical trials. The small representation of women in clinical trials and the fewer rates of events due to the lower female baseline CVD risk may have conditioned contradictory meta-analysis findings. Specifically, benefits outweigh disadvantages of statin therapy in women with a high CVD risk, while several doubts exist for the primary prevention of women at low-intermediate CVD risk. Furthermore, disparities between women and men in medication adherence may influence statin efficacy in CVD prevention. The sex-dependent impact of adverse side effects is one of the reasons advocated for explaining the gender gap, but it is not evidence-proved.
The present review summarizes the sex and gender differences in the use of statins, pointing out new perspectives and opening issues in sex-tailored CVD prevention strategy.Export Options
About this article
Cite this article as:
Raparelli Valeria, Pannitteri Gaetano, Todisco Tommaso, Toriello Filippo, Napoleone Laura, Manfredini Roberto and Basili Stefania*, Treatment and Response to Statins: Gender-related Differences, Current Medicinal Chemistry 2017; 24 (24) . https://dx.doi.org/10.2174/0929867324666161118094711
DOI https://dx.doi.org/10.2174/0929867324666161118094711 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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