Abstract
Background: Thiazole ring is one of the most important heterocyclic ring systems due to their wide range of biological activities.
Objective: we became interested in synthesizing a new series of thiazole derivatives to investigate their antitumor activity against liver and colon cancer cell lines. Method: A novel series of 5-arylazothiazoles was prepared from 2-(-1-morpholino-1-(2-arylhydrazono)propan-2- ylidene)-hydrazinecarbothioamide by different methods. Results: The structures of the newly synthesized compounds were established on the basis of spectroscopic evidences and their synthesis by alternative methods. The newly synthesized products were evaluated for their anticancer activities and the results reveal that some derivatives show good to moderate activity against hepatocellular (HepG2) and colorectal (HCT-116) carcinoma cell lines. Moreover, the computational studies using MOE 2014.09 software are in full support of the results in biological activity. Conclusion: A new bioactive series of thiazole ring was synthesized and showed promising activities against hepatocellular (HepG2) and colorectal (HCT-116) carcinoma cell lines.Keywords: Cyclocondensation, hydrazonoyl chlorides, arylazothiazoles, anti-cancer activity, docking study.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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