Abstract
Glucocorticoids are the most widely used drugs for the treatment of hypersensitivity, however these drugs themselves and the excipients contained in commercial corticosteroid formulations are able to induce severe immediate-type hypersensitivity reactions. Reactions involving excipients have been confirmed to be IgE mediated by the demonstration of specific-IgE to excipients such as carboxymethylcellulose and lactose. In case of hypersensitivity reactions to corticosteroid preparations, a complete allergy work-up with skin tests and/or challenge tests should include testing excipients as well as the active ingredients.
Keywords: Anaphylaxis, carboxymethylcellulose, excipients, glucocorticoids, hypersensitivity, lactose, macrogols, povidone.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations
Volume: 15 Issue: 2
Author(s): Gianfranco Calogiuri, Lene H. Garvey, Paolo Romita, Luigi Macchia and Caterina Foti
Affiliation:
Keywords: Anaphylaxis, carboxymethylcellulose, excipients, glucocorticoids, hypersensitivity, lactose, macrogols, povidone.
Abstract: Glucocorticoids are the most widely used drugs for the treatment of hypersensitivity, however these drugs themselves and the excipients contained in commercial corticosteroid formulations are able to induce severe immediate-type hypersensitivity reactions. Reactions involving excipients have been confirmed to be IgE mediated by the demonstration of specific-IgE to excipients such as carboxymethylcellulose and lactose. In case of hypersensitivity reactions to corticosteroid preparations, a complete allergy work-up with skin tests and/or challenge tests should include testing excipients as well as the active ingredients.
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Cite this article as:
Calogiuri Gianfranco, Garvey H. Lene, Romita Paolo, Macchia Luigi and Foti Caterina, Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2016; 15 (2) . https://dx.doi.org/10.2174/1871523016666161109144021
DOI https://dx.doi.org/10.2174/1871523016666161109144021 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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