Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Structural Modifications of Matrine-Type Alkaloids

Author(s): Xiao-Hua Cai*, Hui Guo* and Bing Xie

Volume 18, Issue 9, 2018

Page: [730 - 744] Pages: 15

DOI: 10.2174/1389557516666161104150334

Price: $65

Abstract

Matrine-type alkaloids belong to quinolizidine analogues from Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L. possess numerous therapeutic properties and have attracted continuous attention over the past few decades. In order to improve the activities and amplify their applicants, many matrine-type derivatives have synthesized and evaluated for their biological activities in recent years. These structural modifications have resulted in stronger activities and improvement of the pharmacokinetic properties. The structure and activity relation studies based on matrine- type semi-synthetic derivatives have immensely contributed to the understanding of their mechanism of actions and molecular targets. This review mainly summarizes recent progress in the structural modifications of matrine-type alkaloids based on the alteration of C-13 or C-14 position, opening D ring, fusing D ring and structural simplification.

Keywords: Bioactivities, Chinese traditional medicine, matrine, matrine-type alkaloids, sophoridine, structural modifications.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy