The Role of Clusterin in Carcinogenesis and its Potential Utility as Therapeutic Target

Title:The Role of Clusterin in Carcinogenesis and its Potential Utility as Therapeutic Target

Volume: 23 Issue: 38

Author(s): T. Tellez, M. Garcia-Aranda and M. Redondo

Affiliation:

Keywords: Clusterin, cancer, apoptosis, chemotherapy, antisense oligonucleotides, targeted therapy.

Abstract: Clusterin is a glycoprotein that has been implicated in many processes, including apoptosis, cell cycle regulation and DNA repair. Since clusterin expression has also been associated with tumorigenesis and the progression of various malignancies including prevalent tumors like prostate, colon, bladder and breast, this protein has been proposed as a good candidate for future treatments.

There have been numerous studies conducted in cell lines and xenograft models with successful results that, in general, justify the use of clusterin as a therapeutic target. However, it is still necessary to continue with these studies in order to achieve a better understanding of the role of this protein in carcinogenesis and to determine those specific situations in which its therapeutic use may be more favorable.

In this review, we will make a brief description of clusterin structure and genetics, its implication in tumorigenesis and cancer progression and its prognosis utility. Finally, we will analyze the effects of clusterin inhibition in different types of cancer.

Cite this article as:

Tellez T., Garcia-Aranda M. and Redondo M., The Role of Clusterin in Carcinogenesis and its Potential Utility as Therapeutic Target, Current Medicinal Chemistry 2016; 23 (38) . https://dx.doi.org/10.2174/0929867323666161024150540