Abstract
Excessive and persistent formation of ROS (reactive oxygen species) is a key factor in the origin of cancer, cardiac problems, inflammatory diseases, multiple organ dysfunction, aging and neurogenerative diseases. These ROS are produced from exogenous sources (ionizing radiation, chemicals and contaminants) and endogenous sources (Enzymes like Xanthine Oxidase and Monoamine Oxidase) which further originate a number of diseases along with genetic mutation. Due to the persistent side effects of synthetic antioxidants, there is flow towards naturally driven antioxidants as a large number of dietary supplements possess antioxidant potential. Coumarins are naturally occurring benzopyrones found in a variety of natural plants and exhibit different pharmacological properties. Among these activities the antioxidant potential of coumarins has been extensively studied that has been reviewed in this paper.
Keywords: Antioxidant, xanthine oxidase, monoamine oxidase, coumarins.
Current Organic Chemistry
Title:Antioxidant, Xanthine Oxidase and Monoamine Oxidase Inhibitory Potential of Coumarins: A Review
Volume: 21 Issue: 4
Author(s): Priyanka Dhiman, Neelam Malik, Anurag Khatkar and Mahesh Kulharia
Affiliation:
Keywords: Antioxidant, xanthine oxidase, monoamine oxidase, coumarins.
Abstract: Excessive and persistent formation of ROS (reactive oxygen species) is a key factor in the origin of cancer, cardiac problems, inflammatory diseases, multiple organ dysfunction, aging and neurogenerative diseases. These ROS are produced from exogenous sources (ionizing radiation, chemicals and contaminants) and endogenous sources (Enzymes like Xanthine Oxidase and Monoamine Oxidase) which further originate a number of diseases along with genetic mutation. Due to the persistent side effects of synthetic antioxidants, there is flow towards naturally driven antioxidants as a large number of dietary supplements possess antioxidant potential. Coumarins are naturally occurring benzopyrones found in a variety of natural plants and exhibit different pharmacological properties. Among these activities the antioxidant potential of coumarins has been extensively studied that has been reviewed in this paper.
Export Options
About this article
Cite this article as:
Dhiman Priyanka, Malik Neelam, Khatkar Anurag and Kulharia Mahesh, Antioxidant, Xanthine Oxidase and Monoamine Oxidase Inhibitory Potential of Coumarins: A Review, Current Organic Chemistry 2017; 21 (4) . https://dx.doi.org/10.2174/1385272820666161021103547
DOI https://dx.doi.org/10.2174/1385272820666161021103547 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Biomedical Application of Polymers: A Case Study of Non-CNS Drugs Becoming CNS Acting Drugs
Central Nervous System Agents in Medicinal Chemistry The Role and Impact of SNPs in Pharmacogenomics and Personalized Medicine
Current Drug Metabolism Atrial Tachycardias Occurring Late After Open Heart Surgery
Current Cardiology Reviews Cellular Signaling in Cartilage Tissue Engineering
Current Signal Transduction Therapy Design, Synthesis and Molecular Docking Study of Some Substituted 4,5- dihydro-2H-indazole Derivatives as Potential Anti-inflammatory Agents
Medicinal Chemistry Pathophysiological Bases of Eosinophilic Esophagitis Therapy
Inflammation & Allergy - Drug Targets (Discontinued) Biopharmaceutics, Pharmacokinetics and Pharmacodynamics of Antituberculosis Drugs
Current Medicinal Chemistry Donors of HNO
Current Topics in Medicinal Chemistry Ruthenium Complexes as Anticancer Agents
Current Medicinal Chemistry Plant Secondary Metabolites in Cancer Chemotherapy: Where are We?
Current Pharmaceutical Biotechnology Novel Antiviral Strategies to Combat Human Arenavirus Infections
Current Molecular Medicine Novel Paramagnetic Contrast Agents for Molecular Imaging and Targeted Drug Delivery
Current Pharmaceutical Biotechnology Peptidomimetics - Antagonists of the Fibrinogen Receptors: Molecular Design, Structures, Properties and Therapeutic Applications
Current Medicinal Chemistry Modulators of Protein-Protein Interactions – Novel Approaches in Targeting Protein Kinases and Other Pharmaceutically Relevant Biomolecules
Current Topics in Medicinal Chemistry Dependence of DPPH Radical Scavenging Activity of Dietary Flavonoid Quercetin on Reaction Environment
Mini-Reviews in Medicinal Chemistry Metabotropic Glutamate Receptors in Central Nervous System Diseases
Current Drug Targets Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs
Current Drug Targets Binding of Reactive Brilliant Red to Human Serum Albumin: Insights into the Molecular Toxicity of Sulfonic Azo Dyes
Protein & Peptide Letters Virtual Screening and Molecular Docking: Discovering Novel c-KIT Inhibitors
Current Medicinal Chemistry Pituitary Stem Cells Drop Their Mask
Current Stem Cell Research & Therapy