Abstract
Background: The growing interest on the redox modulation in living systems broadly involved selenium derivatives that during the last twenty years were often claimed powerful antioxidants but that were also clearly correlated to several important biological effects sometimes, unfortunately, associated to a certain toxicity. Comparing the antioxidant activity of different organoselenium structures it can be observed that sometimes quite different reaction mechanisms are involved.
Method: We propose here a classification based on the nature of the selenenylated functional group. Beside the natural glutathione peroxidase-like activity, other biological interactions were proposed and we report now an overview of the state of art pointing the attention also to the testes used to evaluate and demonstrate the biological activity.
Conclusion: New prospective on the use of selenium and tellurium derivatives as Redox modulators, were discussed throughout a series of selected examples. The possibility to obtain from organoselenium derivatives molecules endowed with hormetic effect or able to act as selective inhibitor of specific enzyme will be discussed.
Keywords: Selenium, tellurium, redox, ROS, antioxidant, diselenide, selenide, ebselen.
Current Organic Chemistry
Title:New Prospective for Redox Modulation Mediated by Organo selenium and Organotellurium Compounds
Volume: 21 Issue: 20
Author(s): Angelita M. Barcellos, Laura Abenante, Maria Teresa Sarro, Iris Di Leo, Eder J. Lenardao, Gelson Perin*Claudio Santi*
Affiliation:
- LASOL - CCQFA - Universidade Federal de Pelotas - UFPel - P.O. Box 354 - 96010-900, Pelotas, RS,Brazil
- Dipartimento di Chimica e Tecnologia del Farmaco, via del Liceo 1- 06136 Perugia,Italy
Keywords: Selenium, tellurium, redox, ROS, antioxidant, diselenide, selenide, ebselen.
Abstract: Background: The growing interest on the redox modulation in living systems broadly involved selenium derivatives that during the last twenty years were often claimed powerful antioxidants but that were also clearly correlated to several important biological effects sometimes, unfortunately, associated to a certain toxicity. Comparing the antioxidant activity of different organoselenium structures it can be observed that sometimes quite different reaction mechanisms are involved.
Method: We propose here a classification based on the nature of the selenenylated functional group. Beside the natural glutathione peroxidase-like activity, other biological interactions were proposed and we report now an overview of the state of art pointing the attention also to the testes used to evaluate and demonstrate the biological activity.
Conclusion: New prospective on the use of selenium and tellurium derivatives as Redox modulators, were discussed throughout a series of selected examples. The possibility to obtain from organoselenium derivatives molecules endowed with hormetic effect or able to act as selective inhibitor of specific enzyme will be discussed.
Export Options
About this article
Cite this article as:
Barcellos M. Angelita, Abenante Laura, Sarro Teresa Maria, Leo Di Iris, Lenardao J. Eder, Perin Gelson*, Santi Claudio*, New Prospective for Redox Modulation Mediated by Organo selenium and Organotellurium Compounds, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272820666161020162113
DOI https://dx.doi.org/10.2174/1385272820666161020162113 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cognitive Function and Quality of Life in Mild Thyroid Hormone Deficiency
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Regulation of Glycolytic and Mitochondrial Metabolism by Ras
Current Pharmaceutical Biotechnology β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid
Current Cancer Drug Targets The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part III: Specific Management and Surgical Aspects
Current Cardiology Reviews A Disposable, Highly Sensitive Biosensing System: Determination of Haptoglobin as a Significant Acute Phase Biomarker
Current Analytical Chemistry Strategies for the Assessment of Metabolic Profiles of Steroid Hormones in View of Diagnostics and Drug Monitoring: Analytical Problems and Challenges
Current Drug Metabolism Natural Products in Structure-Assisted Design of Molecular Cancer Therapeutics
Current Pharmaceutical Design Can Trehalose Prevent Neurodegeneration? Insights from Experimental Studies
Current Drug Targets Systemic Administration of Fluoro-Gold for the Histological Assessment of Vascular Structure, Integrity and Damage
Current Neurovascular Research Neuroprotective and Preventative Effects of Molecular Hydrogen
Current Pharmaceutical Design New Insights in Prolactin Releasing Peptide (Prrp) in the Brain
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Molecular Mechanisms of Biological Activity of Oleanolic Acid - A Source of Inspiration for A New Drugs Design
Mini-Reviews in Organic Chemistry Small-molecule Inhibitors of Epigenetic Mutations as Compelling Drugtargets for Myelodysplastic Syndromes
Current Cancer Drug Targets Role of Fractalkine (CX3CL1) in Regulating Neuron-Microglia Interactions: Development of Viral-Based CX3CR1 Antagonists
Current Alzheimer Research Preface [Hot Topic: Advances in the Four Pillars of Alzheimer Disease Research: Pathobiology, Genetics, Diagnosis, and Treatment (Debomoy K. Lahiri)]
Current Alzheimer Research subject Index To Volume 4
Combinatorial Chemistry & High Throughput Screening Curcuminoids in Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery (Discontinued) A Pathological Brain Detection System based on Extreme Learning Machine Optimized by Bat Algorithm
CNS & Neurological Disorders - Drug Targets G-Protein Coupled Receptor Resensitization - Appreciating the Balancing Act of Receptor Function
Current Molecular Pharmacology Molecular Manipulation Targeting Regulation of Dopaminergic Differentiation and Proliferation of Neural Stem Cells or Pluripotent Stem Cells
CNS & Neurological Disorders - Drug Targets