Microwave Assisted Copper-catalyzed Synthesis of Substituted Benzamides Through Decarboxylative C-N Cross Coupling

Author(s): Aniket P. Sarkate*, Dattatraya N. Pansare, Kshipra S. Karnik, Ishwari A. Kale, Sushilkumar S. Bahekar, Devanand B. Shinde

Journal Name: Current Microwave Chemistry

Volume 4 , Issue 2 , 2017

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Graphical Abstract:


Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for substituted benzamides has been developed by using salts of carboxylic acids.

Methods: In the synthetic method, the targeted substituted benzamides were synthesized with the help of microwave by reacting salts of carboxylic acid and benzamides in the presence of copper and dimethyl formamide.

Results: All substituted benzamides were obtained in good yield (93-99%) with the help of a microwave technique (12-15 min) in the less time as compared to the conventional method.

Conclusion: Microwave assisted technique will be a useful alternative protocol for the preparation of diverse range of substituted benzamides.

Keywords: Benzamides, copper, coupling, microwave, synthesis.

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Article Details

Year: 2017
Published on: 15 May, 2017
Page: [163 - 167]
Pages: 5
DOI: 10.2174/2213335603666161017120230
Price: $25

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