Abstract
Traditional technologies using reductionist approach are relatively insufficient to solve problems in a biological system. Rather than a reductionist approach, systems biology uses a holistic and integrative approach to better figure out the whole process. Both qualitatively and quantitatively of biological system provide information about diseases, toxicities, therapies etc. Omics technologies, which systems biology brings, are valuable tools for comprehensive analyses. Automated DNA sequencers enabled the sequencing of genomes; microarray and mass spectrometry analysis permit global transcriptional profiling and lead to large-scale proteomic and metabolomics analysis. These high-throughput data need to be interpreted by bioinformatics. So far there has been no concrete published paper that compiles omics technologies according to PubMed database. In the present review, it was aimed to give brief description of systems biology and information on the advantages and disadvantages of omics technologies.
Keywords: Systems biology, omics technologies, genomics, transcriptomics, proteomics, metabolomics.
Current Medicinal Chemistry
Title:Overview of Systems Biology and Omics Technologies
Volume: 23 Issue: 37
Author(s): Bensu Karahalil
Affiliation:
Keywords: Systems biology, omics technologies, genomics, transcriptomics, proteomics, metabolomics.
Abstract: Traditional technologies using reductionist approach are relatively insufficient to solve problems in a biological system. Rather than a reductionist approach, systems biology uses a holistic and integrative approach to better figure out the whole process. Both qualitatively and quantitatively of biological system provide information about diseases, toxicities, therapies etc. Omics technologies, which systems biology brings, are valuable tools for comprehensive analyses. Automated DNA sequencers enabled the sequencing of genomes; microarray and mass spectrometry analysis permit global transcriptional profiling and lead to large-scale proteomic and metabolomics analysis. These high-throughput data need to be interpreted by bioinformatics. So far there has been no concrete published paper that compiles omics technologies according to PubMed database. In the present review, it was aimed to give brief description of systems biology and information on the advantages and disadvantages of omics technologies.
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Cite this article as:
Karahalil Bensu, Overview of Systems Biology and Omics Technologies, Current Medicinal Chemistry 2016; 23 (37) . https://dx.doi.org/10.2174/0929867323666160926150617
DOI https://dx.doi.org/10.2174/0929867323666160926150617 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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