Abstract
Background: Although several methods are reported for the synthesis of thiazolidin-4-ones analogues, the microwave assisted method reported in this work is simple and proceeds with high yields in short time.
Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of zirconium oxychloride and ethanol. Results: All the thiazolidin-4-ones were obtained in good yield (95%-98%) with the help of a microwave technique (6-8 min), in less time as compared to the conventional method (2-4 h). Conclusion: Microwave assisted synthesis will be a useful alternative method for the synthesis of diverse range of thiazolidin-4-ones.Keywords: Aromatic aldehydes, microwave irradiation, ZrOCl2·8H2O.
Current Microwave Chemistry
Title:Microwave and Conventional Method Assisted Synthesis of 2-(substituted) -3-(4-methoxybenzyl) Thiazolidin-4-ones Using ZrOCl2·8H2O as a Catalyst
Volume: 4 Issue: 2
Author(s): Aniket P. Sarkate*, Dattatraya N. Pansare, Ishwari A. Kale and Devanand B. Shinde
Affiliation:
- Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS,India
Keywords: Aromatic aldehydes, microwave irradiation, ZrOCl2·8H2O.
Abstract: Background: Although several methods are reported for the synthesis of thiazolidin-4-ones analogues, the microwave assisted method reported in this work is simple and proceeds with high yields in short time.
Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of zirconium oxychloride and ethanol. Results: All the thiazolidin-4-ones were obtained in good yield (95%-98%) with the help of a microwave technique (6-8 min), in less time as compared to the conventional method (2-4 h). Conclusion: Microwave assisted synthesis will be a useful alternative method for the synthesis of diverse range of thiazolidin-4-ones.Export Options
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Cite this article as:
Sarkate P. Aniket*, Pansare N. Dattatraya, Kale A. Ishwari and Shinde B. Devanand, Microwave and Conventional Method Assisted Synthesis of 2-(substituted) -3-(4-methoxybenzyl) Thiazolidin-4-ones Using ZrOCl2·8H2O as a Catalyst, Current Microwave Chemistry 2017; 4 (2) . https://dx.doi.org/10.2174/2213335603666160922115342
DOI https://dx.doi.org/10.2174/2213335603666160922115342 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
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