Abstract
Acute kidney injury (AKI) is manifested by inflammation, and an early feature in the pathogenesis is the accumulation of immune cells in the kidney. Natural killer T (NKT) cells, a peculiar T cells subtype, serve as a bridge between innate and adaptive immunity. Due to the difference between type I and type II subsets, NKT cells were supposed to play a dual role in IR-related tissue injury. Furthermore, membrane receptors and clinical immunosuppressive agents remain involved in the modulation of NKT cell function. Therefore, regulation of the amount and viability of NKT cells becomes a potential strategy in amelioration of AKI. This review will highlight the recent insights gained into the role and mechanisms of NKT cells in AKI.
Keywords: NKT cells, inflammation, acute kidney injury, angel or evil, pathogenesis, immunity.
Current Protein & Peptide Science
Title:The Role of Natural Killer T Cells in Acute Kidney Injury: Angel or Evil?
Volume: 18 Issue: 12
Author(s): Chao Hu, Chao Zhang and Cheng Yang*
Affiliation:
- Department of Urology, Zhongshan Hospital, Fudan University; Shanghai Key Laboratory of Organ Transplantation, 180 Fenglin Road, Shanghai 200032,China
Keywords: NKT cells, inflammation, acute kidney injury, angel or evil, pathogenesis, immunity.
Abstract: Acute kidney injury (AKI) is manifested by inflammation, and an early feature in the pathogenesis is the accumulation of immune cells in the kidney. Natural killer T (NKT) cells, a peculiar T cells subtype, serve as a bridge between innate and adaptive immunity. Due to the difference between type I and type II subsets, NKT cells were supposed to play a dual role in IR-related tissue injury. Furthermore, membrane receptors and clinical immunosuppressive agents remain involved in the modulation of NKT cell function. Therefore, regulation of the amount and viability of NKT cells becomes a potential strategy in amelioration of AKI. This review will highlight the recent insights gained into the role and mechanisms of NKT cells in AKI.
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Cite this article as:
Hu Chao, Zhang Chao and Yang Cheng*, The Role of Natural Killer T Cells in Acute Kidney Injury: Angel or Evil?, Current Protein & Peptide Science 2017; 18 (12) . https://dx.doi.org/10.2174/1389203717666160909151725
DOI https://dx.doi.org/10.2174/1389203717666160909151725 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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