Abstract
The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine.
Keywords: The extracellular matrix, biological scaffold, microenviroment, tissue repair and regeneration, clinical application, tissue engineering.
Current Stem Cell Research & Therapy
Title:Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine
Volume: 12 Issue: 3
Author(s): Sheng Yi, Fei Ding, Leiiei Gong and Xiaosong Gu
Affiliation:
Keywords: The extracellular matrix, biological scaffold, microenviroment, tissue repair and regeneration, clinical application, tissue engineering.
Abstract: The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine.
Export Options
About this article
Cite this article as:
Yi Sheng, Ding Fei, Gong Leiiei and Gu Xiaosong, Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine, Current Stem Cell Research & Therapy 2017; 12 (3) . https://dx.doi.org/10.2174/1574888X11666160905092513
DOI https://dx.doi.org/10.2174/1574888X11666160905092513 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
Current Pharmaceutical Design Growth Factors and Chemokines: A Comparative Functional Approach Between Invertebrates and Vertebrates
Current Medicinal Chemistry Transforming Growth Factor-β Signaling in Motor Neuron Diseases
Current Molecular Medicine Increased Paternal Age and Child Health and Development
Current Pediatric Reviews Notch Signaling in Cardiovascular Disease and Calcification
Current Cardiology Reviews Potential Replication of Induced Pluripotent Stem Cells for Craniofacial Reconstruction
Current Stem Cell Research & Therapy Sudden Unexpected Death in Infancy (SUDI) — The Role of the Pathologist
Current Pediatric Reviews Novel Methods of Genetic Modification of Human Pluripotent Stem Cells
Recent Patents on Regenerative Medicine Periostin as a Heterofunctional Regulator of Cardiac Development and Disease
Current Genomics Human Induced Pluripotent Stem Cells for Inherited Cardiovascular Diseases Modeling
Current Stem Cell Research & Therapy Antibody Targeting of TGF-β in Cancer Patients
Current Pharmaceutical Biotechnology Spontaneous Isolated Dissection of Iliac Artery: Unique Vascular Event Resulting from Various Etiologies
Vascular Disease Prevention (Discontinued) Pediatrics for Disability: A Comprehensive Approach to Children with Syndromic Psychomotor Delay
Current Pediatric Reviews Studies on Nonsense Mediated Decay Reveal Novel Therapeutic Options for Genetic Diseases
Recent Patents on DNA & Gene Sequences Chest Pain in Children
Current Pediatric Reviews Management of Incidental Findings in the Era of Next-generation Sequencing
Current Genomics Big Data and Genome Editing Technology: A New Paradigm of Cardiovascular Genomics
Current Cardiology Reviews Pleiotropic Effects of ARB in Vascular Metabolism - Focusing on Atherosclerosis-Based Cardiovascular Disease
Current Vascular Pharmacology Identification of Candidate Biomarkers of Acute Aortic Dissection
Recent Patents on DNA & Gene Sequences Management and Outcomes of Aortic Dissection in Pregnancy with Marfan Syndrome: A Systematic Review
Current Vascular Pharmacology