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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

The Role of Drug Transporters in the Pharmacokinetics of Antibiotics

Author(s): Wen Jin Hua, Wei Xiao Hua, Zhou Jian, Peng Hong Wei, Lu Yan Ni, Li Yu Hua, Cao Duan Wen, Zhou Ying and Cao Li

Volume 17, Issue 8, 2016

Page: [799 - 805] Pages: 7

DOI: 10.2174/1389200217666160629114449

Price: $65

Abstract

Background: Various transporters, including efflux transporters and uptake transporters, play an important role in the pharmacokinetics of drugs. Currently, studies suggest that several antibiotics also serve as substrates for transporters. In addition, these antibiotics are usually combined with other drugs to treat diseases, more effectively. Therefore, it is necessary to focus on the role of transporters in pharmacokinetics and drug-drug interactions of antibiotics.

Methods: This review summarizes the findings of recent studies as well as information retrieved from several databases (until June 2015): ISI Web of KnowledgeSM (ISI WoK), SciFinder (Caplus, Medline, Registry, Casreact, Chrmlist, and Chemcasts) and PubMed (indexed for Medline).

Results: The present review provides useful information for the study of transporters in the pharmacokinetics and drug-drug interactions of antibiotics, and should assist researchers investigating these topics.

Conclusion: The drug transporters mediate intestinal absorption, hepatic uptake, and kidney or biliary excretion. It is necessary to focus on drug-drug interactions when these antibiotics are combined with other chemical substances that are also the substrates for transporters.

Keywords: Antibiotics, BCRP, drug transporters, MRP, OATP, P-gp.

Graphical Abstract

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