Abstract
Glucose and lipid are the major energy sources, and pivotal components of organic metabolism in mammals. Inappropriate diet directly influences the metabolic rate, and can alter the body’s homeostasis. The underlying changes in energy storage and utilization would manifest as metabolic syndrome including obesity and high blood pressure, and high blood glucose, which are predisposing factors that significantly increase the risk for cardiovascular diseases and Type 2 Diabetes (T2D). Thus, it is essential to identify the genes that are involved in the process of glucose and lipid metabolism. Utilizing current advanced scientific methodology and technology, as well as computational resources has led to discovery of many novel genes with major roles in energy metabolism. In addition, many studies have focused on the functional analysis of the novel genes. Nowadays, uncovering the genes that are involved in glucose and lipid storage and utilization, as well as underlying pathways that regulate expression of those genes is an area of ongoing research. Here, we summarize the current research related to the novel genes regulating glucose and lipid metabolisms, which enable us to develop more efficient means of prevention and management of metabolic diseases such as T2D, obesity, high blood glucose, and hypertension.
Keywords: Gene, glucose metabolism, lipid metabolism, metabolic diseases, mammals.
Current Protein & Peptide Science
Title:Discovery of Novel Genes Mediating Glucose and Lipid Metabolisms
Volume: 18 Issue: 6
Author(s): Pingting Guo, Yuan Li, Shabnam Eslamfam, Wei Ding*Xi Ma*
Affiliation:
- Department of geriatrics, Shanghai General Hospital, Medical College, Shanghai Jiaotong University, NO 100. Haining Road, Shanghai, 200080,China
- State Key Lab of Animal Nutrition, China Agricultural University, Beijing, 100193,China
Keywords: Gene, glucose metabolism, lipid metabolism, metabolic diseases, mammals.
Abstract: Glucose and lipid are the major energy sources, and pivotal components of organic metabolism in mammals. Inappropriate diet directly influences the metabolic rate, and can alter the body’s homeostasis. The underlying changes in energy storage and utilization would manifest as metabolic syndrome including obesity and high blood pressure, and high blood glucose, which are predisposing factors that significantly increase the risk for cardiovascular diseases and Type 2 Diabetes (T2D). Thus, it is essential to identify the genes that are involved in the process of glucose and lipid metabolism. Utilizing current advanced scientific methodology and technology, as well as computational resources has led to discovery of many novel genes with major roles in energy metabolism. In addition, many studies have focused on the functional analysis of the novel genes. Nowadays, uncovering the genes that are involved in glucose and lipid storage and utilization, as well as underlying pathways that regulate expression of those genes is an area of ongoing research. Here, we summarize the current research related to the novel genes regulating glucose and lipid metabolisms, which enable us to develop more efficient means of prevention and management of metabolic diseases such as T2D, obesity, high blood glucose, and hypertension.
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Cite this article as:
Guo Pingting, Li Yuan, Eslamfam Shabnam, Ding Wei*, Ma Xi*, Discovery of Novel Genes Mediating Glucose and Lipid Metabolisms, Current Protein & Peptide Science 2017; 18 (6) . https://dx.doi.org/10.2174/1389203717666160627084304
DOI https://dx.doi.org/10.2174/1389203717666160627084304 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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