Abstract
Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.
Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.
Mini-Reviews in Medicinal Chemistry
Title:Spirooxindoles as Potential Pharmacophores
Volume: 17 Issue: 16
Author(s): Siva S. Panda*, Rachel A. Jones, Praveen Bachawala and Prabhu P. Mohapatra
Affiliation:
- Department of Chemistry & Physics, Augusta University, Augusta, GA 30912,United States
Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.
Abstract: Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.
Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
Export Options
About this article
Cite this article as:
Panda S. Siva *, Jones A. Rachel , Bachawala Praveen and Mohapatra P. Prabhu , Spirooxindoles as Potential Pharmacophores, Mini-Reviews in Medicinal Chemistry 2017; 17 (16) . https://dx.doi.org/10.2174/1389557516666160624125108
DOI https://dx.doi.org/10.2174/1389557516666160624125108 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synthesis and Biological Activity of Pyrazolo[4,3-c]heterocyclic Derivatives: A Mini Review
Mini-Reviews in Organic Chemistry β-estradiol Induces Mitochondrial Apoptosis in Cervical Cancer through the Suppression of AKT/NF-κB Signaling Pathway
Recent Patents on Anti-Cancer Drug Discovery Anal Cancer: Focus on HIV-Positive Patients in the HAART Era
Current HIV Research Regulation of Apoptosis and Cell Survival by Resveratrol
Mini-Reviews in Organic Chemistry Radiolabelled Probes Targeting Tumor Hypoxia for Personalized Medicine
Current Pharmaceutical Design Synthesis and Biological Evaluation of a Series of 2-(Substitutedphenyl) benzothiazoles
Medicinal Chemistry Selective Cytotoxic Effects of 5-Trifluoromethoxy-<i>1H</i>-indole-2,3-dione 3-Thiosemicarbazone Derivatives on Lymphoid-originated Cells
Anti-Cancer Agents in Medicinal Chemistry Insights into Antimicrobial Peptides from Spiders and Scorpions
Protein & Peptide Letters Nutrient Regulation of Tumor and Vascular Endothelial Cell Proliferation
Current Cancer Drug Targets Screening Novel SAHA Derivatives as Anti-lung Carcinoma Agents: Synthesis, Biological Evaluation, Docking Studies and Further Mechanism Research between Apoptosis and Autophagyetween Apoptosis and Autophagy
Anti-Cancer Agents in Medicinal Chemistry Vehicles for Lipophilic Drugs: Implications for Experimental Design, Neuroprotection, and Drug Discovery
Current Neurovascular Research A Review on Extraction, Synthesis and Anticancer Activity of Betulinic Acid
Current Bioactive Compounds Applications of HPLC-MALDI-TOF MS/MS Phosphoproteomic Analysis in Oncological Clinical Diagnostics
Current Proteomics Fibroblast Growth Factor Receptor Signaling in Cancer Biology and Treatment
Current Signal Transduction Therapy The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections
Current Molecular Medicine Multifuntional Nanoparticles: Preparation and Applications in Biomedicine and in Non-Invasive Bioimaging
Recent Patents on Nanotechnology Neural Plasticity After Spinal Cord Injury
Current Pharmaceutical Design Contemporary Progress in the Synthetic Strategies of Imidazole and its Biological Activities
Current Organic Synthesis Development of Human Papillomavirus (HPV) Vaccines: A Review of Literature and Clinical Update
Reviews on Recent Clinical Trials Current Management of Chordoma
Current Drug Therapy