Gentiopicroside is a secoiridoid compound isolated from Gentiana lutea which is called Qin
Jiao in Chinese. It is one of the most common herbal medicines used in China. In this article, we review
the pharmacological and biological activity (antiviral, anti-inflammatory, analgesia, antihepatotoxic and
choleretic), as well as biotransformation of the gentiopicroside. In addition, attempt towards the total
synthesis of gentiopicroside is also presented.