Abstract
To investigate the hepatoprotective and in vitro antioxidant activity of aqueous methanolic extract (AME) of polyherbal formulation of Calotropis procera (C. procera), Gymnema sylvestre (G. sylvestre) and Lawsonia inermis (L. inermis) leaves. The activity of the extracts was assessed on the basis of improvement in the altered level of various biochemical parameters in the liver of the rats. The extracts were also investigated for its antioxidant potential by in vitro DPPH radical scavenging assay. The results of present studies strongly indicate that the hepatoprotective and extracts assessed for DPPH free radical scavenging activity, the maximum activity was shown by polyherbal formulation with IC50 value 62.76 µg/ml. Treatment with polyherbal formulation with decreased SGPT, SGOT, ALP, TB and Cholestrol levels in serum demonstrates the hepatoprotective effect of the formulation. Polyherbal formulation revealed excellent hepatoprotective and antioxidant profile as compared to individual plants due to synergistic effect produced by different phytochemicals present in the formulation.
Keywords: Calotropis procera, Carbon tetrachloride, Gymnema sylvestre, Lawsonia inermis.
Current Traditional Medicine
Title:Hepatoprotective Effects and Antioxidant Potential of Polyherbal Formulation Against CCl4- Induced Hepatic Injury in Albino Rats
Volume: 2 Issue: 1
Author(s): Bhumika Yogi and Ashutosh Mishra
Affiliation:
Keywords: Calotropis procera, Carbon tetrachloride, Gymnema sylvestre, Lawsonia inermis.
Abstract: To investigate the hepatoprotective and in vitro antioxidant activity of aqueous methanolic extract (AME) of polyherbal formulation of Calotropis procera (C. procera), Gymnema sylvestre (G. sylvestre) and Lawsonia inermis (L. inermis) leaves. The activity of the extracts was assessed on the basis of improvement in the altered level of various biochemical parameters in the liver of the rats. The extracts were also investigated for its antioxidant potential by in vitro DPPH radical scavenging assay. The results of present studies strongly indicate that the hepatoprotective and extracts assessed for DPPH free radical scavenging activity, the maximum activity was shown by polyherbal formulation with IC50 value 62.76 µg/ml. Treatment with polyherbal formulation with decreased SGPT, SGOT, ALP, TB and Cholestrol levels in serum demonstrates the hepatoprotective effect of the formulation. Polyherbal formulation revealed excellent hepatoprotective and antioxidant profile as compared to individual plants due to synergistic effect produced by different phytochemicals present in the formulation.
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Yogi Bhumika and Mishra Ashutosh, Hepatoprotective Effects and Antioxidant Potential of Polyherbal Formulation Against CCl4- Induced Hepatic Injury in Albino Rats, Current Traditional Medicine 2016; 2 (1) . https://dx.doi.org/10.2174/2215083802666160620131553
DOI https://dx.doi.org/10.2174/2215083802666160620131553 |
Print ISSN 2215-0838 |
Publisher Name Bentham Science Publisher |
Online ISSN 2215-0846 |
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