Abstract
Tissue engineering has emerged as a promising scientific field potentially yielding in vitro developed tissue to replace degenerative or injured tissues in vivo, thus avoiding the donor site morbidity associated with reconstructive surgery. Integral to the process is the role of scaffolds and the biomaterials used to form them. This review explores the concept of scaffold based tissue engineering and design considerations. The scaffold needs to have certain mechanical and architectural properties, it needs to be biocompatible and biodegradable, and allow combination with bioactive molecules. We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development.
Keywords: Biomaterials, bioreactors, fabrication, scaffolds, tissue engineering.
Current Stem Cell Research & Therapy
Title:Biomaterials and Fabrication to Optimise Scaffold Properties for Musculoskeletal Tissue Engineering
Volume: 11 Issue: 7
Author(s): Andrew Wheelton, James Mace, Wasim S. Khan and Sanjay Anand
Affiliation:
Keywords: Biomaterials, bioreactors, fabrication, scaffolds, tissue engineering.
Abstract: Tissue engineering has emerged as a promising scientific field potentially yielding in vitro developed tissue to replace degenerative or injured tissues in vivo, thus avoiding the donor site morbidity associated with reconstructive surgery. Integral to the process is the role of scaffolds and the biomaterials used to form them. This review explores the concept of scaffold based tissue engineering and design considerations. The scaffold needs to have certain mechanical and architectural properties, it needs to be biocompatible and biodegradable, and allow combination with bioactive molecules. We also discuss scaffolding techniques, different biomaterial options and fabrication technologies, and future areas of development.
Export Options
About this article
Cite this article as:
Wheelton Andrew, Mace James, Khan S. Wasim and Anand Sanjay, Biomaterials and Fabrication to Optimise Scaffold Properties for Musculoskeletal Tissue Engineering, Current Stem Cell Research & Therapy 2016; 11 (7) . https://dx.doi.org/10.2174/1574888X11666160614101037
DOI https://dx.doi.org/10.2174/1574888X11666160614101037 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cardiovascular Aspect of Beta-Thalassaemia
Cardiovascular & Hematological Agents in Medicinal Chemistry Filling the Gaps between the In Vivo and In Vitro Microenvironment: Engineering of Spheroids for Stem Cell Technology
Current Stem Cell Research & Therapy Will this be the End of the Anticoagulation Clinic for Patients with Atrial Fibrillation?
Current Drug Targets - Cardiovascular & Hematological Disorders The Road to Device Miniaturization in Echocardiography
Recent Patents on Medical Imaging The Effects of Obesity-Related Peptides on the Vasculature
Current Vascular Pharmacology Inflammatory Cells and Chronic Obstructive Pulmonary Disease
Current Drug Targets - Inflammation & Allergy Prophylactic Neuroprotection
Current Drug Targets Physical Function and Exercise in Older Patients with Cardiovascular and Respiratory Conditions
Current Pharmaceutical Design Drug Discovery and Design for Complex Diseases through QSAR Computational Methods
Current Pharmaceutical Design Pulmonary Arterial Hypertension in HIV-infected Patients
Current Hypertension Reviews Pharmacology of the Human Saphenous Vein
Current Vascular Pharmacology Potential Use of Dendritic Cells for Anti-Atherosclerotic Therapy
Current Pharmaceutical Design Neonatology in the United States: Where we are, and where we are Going
Current Pediatric Reviews Consequences of Secondary Hyperparathyroidism on Vascular Calcification and Cardiovascular Mortality: Potential Benefit of Calcimimetics
Current Drug Therapy Towards Personalized Regenerative Cell Therapy: Mesenchymal Stem Cells Derived from Human Induced Pluripotent Stem Cells
Current Stem Cell Research & Therapy Pharmacogenomics of Oral Antithrombotic Drugs
Current Pharmaceutical Design Valve Endothelial Cells – Not Just Any Old Endothelial Cells
Current Vascular Pharmacology Mixed Connective Tissue Disease (MCTD) – A Coming of Age
Current Rheumatology Reviews The Ignored Role of Intraoperative Hypotension in Producing Postoperative Acute Kidney Injury-An Obligatory Appeal for More Preventative Nephrology
Current Hypertension Reviews Nigella Sativa Improve Redox Homeostasis in Heart and Aorta of Diabetic Rat
Current Nutrition & Food Science