Abstract
Background: Polyheterocyclic compounds have numerous applications in different fields ranging from medicinal chemistry to material science. Cascade reactions represent the most direct and efficient method to obtain polyheterocyclic molecules with functional diversity and increased complexity. Moreover, novel polycyclic systems can be generated which can possess interesting properties such as biological activity or luminescence. The number of polyheterocyclic compounds obtained through cascade reactions, including multi-component reactions, is wide and this review will be limited to polyheterocycles obtained from aromatic N-heterocycles: pyrrole, pyrazole, triazole, pyridine, pyrimidine, indole, benzimidazole, quinoline and other mono- or bicyclic compounds.
Objective: The review will cover the period ranging from 2006 to 2015 and will focus on processes involving the formation of C-N bonds with the heterocyclic nitrogen.Keywords: Cascade reactions, C-N bond, Domino reactions, N-heterocyle, polyheterocycle, tandem reactions.
Current Organic Chemistry
Title:Cascade Reactions Involving Aromatic N-Heterocycles: C-N Bond Formation as Key-step Towards the Synthesis of N-fused Polycyclic Heterocycles
Volume: 21 Issue: 15
Author(s): Victor Mamane*
Affiliation:
- Institut de Chimie de Strasbourg, UMR 7177, LASYROC group, 67070, Strasbourg,France
Keywords: Cascade reactions, C-N bond, Domino reactions, N-heterocyle, polyheterocycle, tandem reactions.
Abstract: Background: Polyheterocyclic compounds have numerous applications in different fields ranging from medicinal chemistry to material science. Cascade reactions represent the most direct and efficient method to obtain polyheterocyclic molecules with functional diversity and increased complexity. Moreover, novel polycyclic systems can be generated which can possess interesting properties such as biological activity or luminescence. The number of polyheterocyclic compounds obtained through cascade reactions, including multi-component reactions, is wide and this review will be limited to polyheterocycles obtained from aromatic N-heterocycles: pyrrole, pyrazole, triazole, pyridine, pyrimidine, indole, benzimidazole, quinoline and other mono- or bicyclic compounds.
Objective: The review will cover the period ranging from 2006 to 2015 and will focus on processes involving the formation of C-N bonds with the heterocyclic nitrogen.Export Options
About this article
Cite this article as:
Mamane Victor*, Cascade Reactions Involving Aromatic N-Heterocycles: C-N Bond Formation as Key-step Towards the Synthesis of N-fused Polycyclic Heterocycles, Current Organic Chemistry 2017; 21 (15) . https://dx.doi.org/10.2174/1385272820666160606155222
DOI https://dx.doi.org/10.2174/1385272820666160606155222 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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