Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one

Title:Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one

Volume: 14 Issue: 2

Author(s): Vinutha V. Salian, Badiadka Narayana, Balladka K. Sarojini, Enumadisetty S. Sindhupriya, Leelavathi N. Madhu and Shama Rao

Affiliation:

Keywords: Pyrazolines, antibacterial, antioxidant, antiproliferative, anti-inflammatory activity, molecular docking

Abstract: A series of new biologically potent N-substitutedpyrazoline derivatives have been synthesized by reacting hydrazine hydrate and its derivatives with (2)-1-(4-chlorophenyl)-3-[4-(propan-2- yl)phenyl]prop-2-en-1-one, which in turn prepared by the base catalysed Claisen-Schmidt condensation reaction of 4-(propan-2-yl)benzaldehyde and 4-chloroacetophenone. All the synthesized compounds, 2a-e, 3a-d, 4a,b and 5a-c were screened for their in vitro antibacterial, antioxidant, antiproliferative properties and compounds 3b, 4b were evaluated for in vivo anti-inflammatory activity. The docking studies were carried out for these compounds against α-amylase with TREX1 (PDB:3B60) to predict their putative interactions. Some of the tested compounds showed significant antibacterial, antioxidant, antiproliferative, anti-inflammatory activity and molecular binding.

Cite this article as:

Salian V. Vinutha, Narayana Badiadka, Sarojini K. Balladka, Sindhupriya S. Enumadisetty, Madhu N. Leelavathi and Rao Shama, Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one, Letters in Drug Design & Discovery 2017; 14 (2) . https://dx.doi.org/10.2174/1570180813666160519151723