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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

The Application of Molecular Tethers in Controlling Axial Chirality

Author(s): Michael Reen and Timothy P. O`Sullivan

Volume 13, Issue 3, 2016

Page: [206 - 218] Pages: 13

DOI: 10.2174/1570193X13666160510114626

Price: $65

Abstract

Atropisomeric biaryl compounds are an attractive target in organic chemistry due to their abundance in nature and their utility as ligands in catalysis. Among the methods available for their synthesis, the use of chiral tethers offers very high levels of stereocontrol. In this article, we review the application of molecular tethers in controlling axial chirality across a range of different ligands and natural products.

Keywords: Atropisomeric biaryl compound, axial chirality, biaryls, stereoinduction, synthesis, tethers.

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