Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)Benzofuran-3-one Derivatives

Title:Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)Benzofuran-3-one Derivatives

Volume: 13 Issue: 6

Author(s): Seref Demirayak, Leyla Yurttas, Ahmet Cagri Karaburun, Nalan Gundogdu-Karaburun and Ismail Kayagil

Affiliation:

Keywords: Antitumor activity, aurone, benzofuranone, chalcone, cytotoxic activity.

Abstract: The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4- chlorobenzylidene)-6-[2-(4-methoxyphenyl)-2-oxoethoxy]benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.

Cite this article as:

Demirayak Seref, Yurttas Leyla, Cagri Karaburun Ahmet, Gundogdu-Karaburun Nalan and Kayagil Ismail, Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)Benzofuran-3-one Derivatives, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180813999160429113316