Abstract
Atherosclerosis is driven by inflammation, with a strong involvement of innate immunity, and involves an expansion of the arterial intima, a normally small area composed of several cell types including smooth muscle cells, lipids, monocytes, macrophages, dendritic cells, and extracellular matrix. Macrophages derived from recruited monocytes are predominant innate immune cells that play crucial roles in the formation of atherosclerotic lesions. Human atherosclerotic plaques have shown that macrophage subsets within a plaque might be more useful for explaining plaque phenotype than just simply giving the total number of macrophages. Therefore, recognizing the roles of macrophage subsets in atherosclerotic plaque formation, progression, and regression would be most helpful for identification of novel strategies to stabilize, or attenuate atherosclerotic lesions. This review discusses the impact of macrophage subsets and their roles in atherosclerosis.
Keywords: Atherosclerosis, Innate immunity, Toll-like receptors, Macrophage, Macrophage polarization, oxLDL.
Current Medicinal Chemistry
Title:Impact of Macrophages in Atherosclerosis
Volume: 23 Issue: 18
Author(s): Xinjie Lu
Affiliation:
Keywords: Atherosclerosis, Innate immunity, Toll-like receptors, Macrophage, Macrophage polarization, oxLDL.
Abstract: Atherosclerosis is driven by inflammation, with a strong involvement of innate immunity, and involves an expansion of the arterial intima, a normally small area composed of several cell types including smooth muscle cells, lipids, monocytes, macrophages, dendritic cells, and extracellular matrix. Macrophages derived from recruited monocytes are predominant innate immune cells that play crucial roles in the formation of atherosclerotic lesions. Human atherosclerotic plaques have shown that macrophage subsets within a plaque might be more useful for explaining plaque phenotype than just simply giving the total number of macrophages. Therefore, recognizing the roles of macrophage subsets in atherosclerotic plaque formation, progression, and regression would be most helpful for identification of novel strategies to stabilize, or attenuate atherosclerotic lesions. This review discusses the impact of macrophage subsets and their roles in atherosclerosis.
Export Options
About this article
Cite this article as:
Lu Xinjie, Impact of Macrophages in Atherosclerosis, Current Medicinal Chemistry 2016; 23 (18) . https://dx.doi.org/10.2174/0929867323666160428105111
DOI https://dx.doi.org/10.2174/0929867323666160428105111 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Low Estimated Glomerular Filtration Rate is Associated with High Recurrence Rate and Poor Prognosis of Hemorrhage Stroke
Current Neurovascular Research Improvement in Hypertension Management with Pharmacological and Non- Pharmacological Approaches: Current Perspectives
Current Pharmaceutical Design Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats
Drug Metabolism Letters Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs
CNS & Neurological Disorders - Drug Targets Clinical Assessment of Carotid Atherosclerosis Inflammation by Positron Emission Tomography
Current Molecular Medicine Conjugation of Resveratrol with RGD and KGD Derivatives
Protein & Peptide Letters Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors
Current Medicinal Chemistry Evidence-Based Percutaneous Closure of the Left Atrial Appendage in Patients with Atrial Fibrillation
Current Cardiology Reviews QT Interval Monitoring and Drugs Management During COVID-19 Pandemic
Current Reviews in Clinical and Experimental Pharmacology The Role of Statins in Preventing the Progression of Congestive Heart Failure in Patients with Metabolic Syndrome
Current Pharmaceutical Design Patent Selections
Recent Patents on Cardiovascular Drug Discovery Implication of Gut Microbiota in Human Health
CNS & Neurological Disorders - Drug Targets Drug-Drug Interactions Associated with Antiplatelet Therapy
Cardiovascular & Hematological Agents in Medicinal Chemistry Cardiac Sarcolemmal Ion Channels and Transporters as Possible Targets for Antiarrhythmic and Positive Inotropic Drugs: Strategies of the Past-Perspectives of the Future
Current Pharmaceutical Design Nutritional Approaches to Modulate Oxidative Stress in Alzheimers Disease
Current Alzheimer Research <i>Thespesia populnea</i>: An Ethnomedicinal, Phytochemical and Pharmacological Review
The Natural Products Journal Premature Ovarian Insufficiency and Long-Term Health Consequences
Current Vascular Pharmacology Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias
Current Cardiology Reviews On the Interaction Between Human IQGAP1 and Actin
Protein & Peptide Letters Imidazoline Receptor Agonists for Managing Hypertension May Hold Promise for Treatment of Intracerebral Hemorrhage
Current Molecular Medicine