ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
Aims & Scope
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Editor(s): Khurshid Zaman and Atta-ur-Rahman
eISBN: 978-981-14-0438-2, 2019
ISBN: 978-981-14-0437-5 ISSN: 2213-3585 (Print) ISSN: 2468-5860 (Online)
Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel
drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer
compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies
targeting cancer stem cells for the treatment of different types of cancers, including myeloma
and renal cell cancer.
eISBN: 978-981-14-7662-4, 2020
ISBN: 978-981-14-7660-0 ISSN: 2213-3585 (Print) ISSN: 2468-5860 (Online)
Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms.
The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers.
The topics covered in this volume are:
- Recent Patents on Exosome-Derived Therapeutic Agents
- Serrated Lesions of the Colon and Rectum: An Overview of Pathology and Emphasis on a New Classification
- Introducing the 188W/188Re and 144Ce/144Pr Plaques for Eye Cancers Brachytherapy
- ShcA Family of Adaptor Proteins: Dual Role in Cell Growth
- Hormones Management as Anticancer Treatment and Protection: Functions and Mechanism of Action
Author(s): Wilhelm Peter Mistiaen
eISBN: 978-1-60805-287-5, 2012
"Degenerative aortic valve disease is the most prominent cardiac valve disease in Western societies. This volume describes some of the more important issues and problems for this condition: its progressive character and the underlying mechanisms of this progression diagnostic difficulties 1) ascertainment of valvular origin of symptoms in elderly; 2) the challenge of the low output – low gradient syndrome; 3) moderate aortic valve calcification during CABG; 4) prediction of the rate of progression (who will need surgery on short term and who not). the burden on the left ventricle and its consequences (danger of postponement of surgery) the effect and the modalities (access, types of valves) of surgical treatment on survival (and QoL) the mode of registering postoperative complications determining predictors for valve related, non-valve related cardiac and non-cardiac postoperative complications. The e-book is a unique presentation, specific to degenerative aortic valve disease and its treatment including information about ways to deal with the progressive character of the disease (autophagy as a mode of cell death). Cardiologists still avoid or delay referring patients to the surgeon for the sake of age, left ventricular function or co-morbidity. Therefore, the e-book benefits readers by addressing the above issue and providing critical information for changing referral policy, which would ultimately enhance postoperative survival of patients suffering from heart valve disease."
Editor(s): Volodymyr Dvornyk
eISBN: 978-1-60805-453-4, 2013
Menopause is a significant event in a woman’s life as is generally considered as an indicator for senescence in women. Evidence suggests that menopause results in many psychological and postmenopausal health problems, such as anxiety, osteoporosis, cardiovascular disease, metabolic disorder and others. Menopausal symptoms and associated disorders are of great importance for public health as they influence the quality of life of affected individuals. Therefore proper management of menopause will definitely contribute to healthy aging and the overall well-being of women.
This e-book reviews recent progress in the research and management of menopause and associated health problems. It provides comprehensive coverage of both clinical aspects and basic research of menopause. Topics covered in this e-book include research findings about risk factors for complex medical conditions associated with menopause along with the treatment options for these conditions, with particular emphasis on hormone replacement therapy (HRT). These conditions include osteoporosis, dementia, cardiovascular diseases, obesity and diabetes mellitus.
Subsequent chapters detail on common oncological malignancies post menopause. The e-book concludes with a review of HRT treatment including its advantages and disadvantages followed by a review on risk factors, causes and complications of premature menopause occurring in women before an age of 40 years.
This e-book is a valuable guide for medical researchers and gynecological professionals with a focus on the pathophysiology and treatment of this medical condition.
Editor(s): Joe Tiralongo and Ivan Martinez-Duncker
eISBN: 978-1-60805-386-5, 2013
This eBook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The importance of substitution by the sugar sialic acid and the role played by sialylated structures (eg. glycoproteins, glycolipids, glycoconjugates) in immune recognition, neural cell growth, embryogenesis and disease development including microbial pathogenesis and cancer progression, has become well-established.
Since 1995, the field of sialobiology has expanded greatly as many of the key enzymes involved in sialic acid biosynthesis, as well as the vast majority of sialic acid binding lectins involved in immune recognition, have only been cloned, characterised and structural eluciated after the publication of earlier works on the subject. This e-book also covers these recent developments. Chapters in this e-book have been contributed by eminent sialobiologists. Therefore, a book of this nature is timely and will prove to be a definitive volume with a high impact in this field for glycobiologists and cell biologists.
Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner
eISBN: 978-1-60805-454-1, 2013
ISBN: 978-1-60805-516-6 ISSN: 2589-2983 (Print) ISSN: 2214-0824 (Online)
Mucins are glycoproteins that are expressed in cells of different types and fulfill multiple functions that determine participation of these proteins in such processes as signal transduction, regulation of gene expression, cell proliferation, embryogenesis, cell differentiation, immunity, apoptosis and cancer development. This E-book series on mucins presents critical reviews on modern data concerning structures and functions of mucins, their roles in cell physiology and pathology as well as molecular aspects of therapy of mucin-associated diseases. Mucins are represented by two types of molecules: secreted mucins and membrane-bound (receptor) mucins. This e-book series represents a unique attempt to describe the molecular nature of mucin multifunctionality in separate volumes. Chapters in each volume demonstrate the central role of mucins as connectors and regulators of different signaling pathways and their participation metastatic processes. Clinical aspects of mucins, such as their role as diagnostic markers as well as possible applications in mucin-based immuno- and gene-therapies are also discussed.
This is the first volume of the series. This volume introduces readers to the general properties of mucins, followed by chapters on specific variants of gel-forming and soluble mucins. The volume concludes with information on the functions of secreted mucins.
Editor(s): Natarajan Singaravelan
eISBN: 978-1-60805-485-5, 2013
Rare Animals of India is a unique book that presents the biological and ecological accounts of the least known animal species of India in one comprehensive volume. The book gives comprehensive ecological accounts supported with data tables on rare and specific animal species of India and discusses the basis for their rarity for their conservation. It includes information about the Indian Gharial (Gavialis gangeticus) the endangered Forest Owlet (Heteroglaux blewitti), the Bengal Marsh Mongoose, Snow Leopards and many more. Readers are guided through several chapters each detailing a specific kind of animal, some of them being on the list of endangered species. With over 150 color illustrations, this intriguing reference will be of immense interest to zoologists, ecologists, naturalists and conservation biologists as well as general readers across the world interested in studying such rare or least known animals found in the length and breadth of the Indian region.
Editor(s): Rahul K. Shah
Co-Editor(s): Diego A. Preciado and George H. Zalzal
eISBN: 978-1-60805-459-6, 2013
Otolaryngology for the Pediatrician serves both as a primer as well as an instant reference for all medical practitioners caring for the pediatric patient. Ear, nose, and throat (ENT) diseases are very common in children and this e-book covers the vast majority of these conditions from an expert viewpoint with data published by respected medical professionals. Topics covered in this e-book include hearing loss, otitis media, neck masses and infections, sinusitis, stridor and many more. Readers with find actionable education needed to help care for their patients presented within simple, easy to read chapters.
Editor(s): Vaclav Vetvicka and Miroslav Novak
eISBN: 978-1-60805-260-8, 2013
ISBN: 978-1-60805-301-8 ISSN: 2211-0526 (Print)
β-Glucan is generally considered to be a very safe immunomodulator. It is a well-known biological response modifier (BRM) that has been used as an adjuvant therapy for cancer since 1980, mostly in Japan. β-Glucan enhances the innate host defense against certain bacteria, yeast, and viral pathogens. I addition, glucans are also considered to be important in prophylaxis against irradiation. Various types of glucans are now routinely added both to human and animal food. At least 26 clinical trials are currently under way in several countries. The authors of this ebook have selected and brought together information on both theoretical and practical aspects of β-glucan use. The book is suitable for readers seeking timely and precise information on β-glucan history and various biological effects including possible use in the treatment of various diseases, without having any preliminary knowledge of natural immunomodulators. The book should not only provide an inspiration for carbohydrate and clinical chemists for further investigations in biomedicine, but it also presents a number of practical applicable results in immunology
Editor(s): Eva Maria Brandtner and John Austin Dangerfield
eISBN: 978-1-60805-720-7, 2013
Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells.
This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.
Editor(s): Alexander B. Poletaev
eISBN: 978-1-60805-724-5, 2013
The book is dedicated to the history and current status of physiologic autoimmunity concept and relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. The main forms of physiological activity of the immune system are based on the intrinsic abilities of self-identification, self-maintenance, self-regulation, and self-reparation — that is recognizing components of the “self ”, i.e. natural autoimmunity. The most ancient and homeostatically important functions of natural autoimmunity are autoclearance as well as construction and support of multicellularity. A considerable number of immune functions, including those related to antimicrobial defense, derive from these basic ones. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonines), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the aff ected organ. This phenomenon is sanogenic in nature and adaptive in essence. Therefore, secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. In relation to experimental production and clinical reveal of antibodies towards nuclear antigens, penetrating into living cell nuclei and altering nuclear acid synthesis, cell proliferation and function, autoantibodies can be regarded as hormone-like bioregulators of gene expression. Apparently, immune system is able to reproduce complementary regulators for various cell receptors, including nuclear ones.
Book is unique, it is a single monograph comprehensively including history and current status of natural autoimmunity problem. It describes a fundamental concept essencial for every branch of Medicine and Pathology. The concept described has broad practical application for Health Care, because it establishes effective method of early prediction for many different diseases, creates a basis for prophylaxis. Reader has a chance to get rid of old dogmas and acquire new instrument for fruitful theoretical reasoning, research planning and predictive/preventive practical medical work.
Editor(s): Ashim K. Mitra
eISBN: 978-1-60805-175-5, 2013
A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic and industrial laboratories.