ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
Aims & Scope
Record not Found
Author(s): Y. Robert Li
eISBN: 978-1-60805-322-3, 2012
Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including cardiovascular diseases, diabetes and metabolic syndrome, neurological disorders, and cancer among many others. This peer-reviewed E-book covers both the fundamental principles and the recent advances in free radical biomedicine along with in-depth discussions of the clinical correlations. It also provides a thorough coverage of the commonly used methods in free radical and antioxidant research with detailed schematic illustrations as well as succinct descriptions of the procedures. This volume should also be a valuable source of information for readers who wish to gain a sound understanding of the research methodologies in this rapidly evolving field.
Editor(s): Yves Henrotin
Co-Editor(s): Kim Bennell and Francois Rannou
eISBN: 978-1-60805-317-9, 2012
Osteoarthritis is a chronic disease prevalent among the elderly. Its most prominent feature is the progressive destruction of articular cartilage which results in impaired joint motion, severe pain and ultimately disability. Its prevalence and its impact on daily life pose a significant public health problem. Today, a cure for osteoarthritis remains elusive and the management of the disease is largely palliative, focusing on the alleviation of symptoms. Current recommendations include a combination of pharmacological and non-pharmacological treatments. The term “non-pharmacological” includes physical therapy and rehabilitation, but also nutraceuticals. All guidelines on osteoarthritis management highlight the importance of weight loss and physical activity to improve the functional status of patients. A number of alternative therapies are also commonly suggested by physicians and physiotherapists in their daily practice. The efficacy of these therapies is not evidenced by strong clinical trials. This category includes education, information, electrotherapy, ultrasound, electromagnetic field, spa, hydrotherapy, acupuncture, etc. Non Pharmacological Therapies in the Management of Osteoarthritis reviews the clinical relevance of these therapies and the difficulties in conducting high quality trials assessing their efficacy. This e-book presents supportive scientific evidence for their efficacy and explains the mechanism of action of nutraceuticals targeting osteoarthritis. It also includes many example of exercises, mobilization and manipulation techniques directly useful for medical professionals.
Editor(s): Augusto Azuara-Blanco
Co-Editor(s): Parwez Hossain and Noemi Lois
eISBN: 978-1-60805-133-5, 2012
This E-book provides the reader with a detailed up-to-date review of diagnostic technologies and their role in clinical practice. Chapters are dedicated specifically to describe the role of current technologies in the management of the leading causes of visual impairment such as age-related macular degeneration, diabetic retinopathy, glaucoma, vitreo-retinal disorders, cornea and anterior segment diseases. This E-book will help clinicians to understand and interpret diagnostic tests and critically appraise their performance and limitations. This book is intended for general ophthalmologists and clinicians with a special interest in retinal diseases, glaucoma, anterior segment and cornea. It will also be of interest and value to ophthalmologists in training, scientists, ophthalmic photographers and optometrists.
Editor(s): Eline P. Meulenberg
eISBN: 978-1-60805-264-6, 2012
Antibodies Applications and New Developments is an overview of the current developments of techniques and methods relating to immunodiagnostics and immunoanalysis. This eBook also deals with specialties in the fields of drug, pesticide, antigen and food contaminant detection. The volume is useful for professional immunologists and biotechnologists interested in antibody research and development.
Author(s): Hernâni Gerós, M. Manuela Chaves and Serge Delrot
eISBN: 978-1-60805-360-5, 2012
Grapes (Vitis spp.) are economically significant fruit species. Many scientific advances have been achieved in understanding physiological, biochemical, and molecular aspects of grape berry maturation. Some of these advances have led to the improvement of wine quality through better grape growing practices; but this avenue of research is still wide open due to the complexity of the biochemical mechanisms involved in the development and ripening of grapes and their response to environment.
The Biochemistry of the Grape Berry is a pioneer offering for readers - giving a focused and integrated coverage of the key biochemical and molecular aspects of grape berry development and ripening. Readers will benefit from a comprehensive and updated coverage on key steps, mechanisms and regulation in grapevine biochemistry and molecular biology, provided by an international team of leading scientists. It provides useful references on this research area and original data from laboratories worldwide. The comprehensive range of topics covered in this e-book is valuable to a multidisciplinary readership including plant physiologists, enologists, microbiologists, wine makers, biochemists and students. Thus The Biochemistry of the Grape Berry represents a step forward in the comprehension of grape berry biochemistry, wine quality and health benefits.
Editor(s): Guangpu Li and Nava Segev
eISBN: 978-1-60805-365-0, 2012
Ypt/Rab GTPases form the largest branch of the Ras-related small GTPase superfamily and regulate intracellular membrane trafficking in all eukaryotes. Since their discovery over two decades ago, a wealth of information has accumulated about the roles that Ypt/Rab proteins play in vesicular transport steps, including vesicle budding, movement, and fusion. In recent years, Ypt/Rab GTPases and membrane trafficking have been discovered to play an important role in other cellular processes, such as signal transduction, cell growth and differentiation. Additionally, Rab GTPases have been implicated in various human diseases, ranging from diabetes to cancer. This e-book provides a timely update on the rapidly developing field and discusses all functional aspects of Ypt/Rab GTPases. The 12 chapters cover well-characterized Ypts/Rabs involved in both exocytic and endocytic pathways as well as newly identified and uncharacterized Rab GTPases. A comprehensive picture about how each Ypt/Rab controls multiple vesicular trafficking steps via interactions with multiple effectors is conveyed to the reader’s mind.
This e-book is the first ever volume focused on the Ypt/Rab GTPases and should provide a useful resource for researchers, students and teachers interested in the field.
Author(s): Mohammed M.S. Jan
eISBN: 978-1-60805-022-2, 2012
Since the last century, remarkable advances at both the basic and clinical levels have considerably improved our ability to evaluate and treat children with neurological disorders. Many cases seen by general pediatricians are primarily neurological accounting for up to 30% of all consultations to pediatrics with a high ratio of follow-up visits to new patients of about 3:1. This manual is a neurology reference for medical students and pediatric residents and is intended to supplement larger textbooks on pediatric neurology already available. Many of undergraduate medical students refer to deficient and oversimplified references that do not enable them to deal with pediatric neurology patients adequately. The manual presents a simplified, organized, and comprehensive problem based approach to common pediatric neurological disorders directed to the level of medical students, pediatric residents, general practitioners and general pediatricians. This e-book is thus a concise outline with practical tips to facilitate proper diagnosis and management of various neurological disorders.
Editor(s): Kuldip S. Sidhu
eISBN: 978-1-60805-289-9, 2012
Pluripotent stem cells have garnered tremendous interest in recent years, which is primarily driven by the hope of finding a cure for several debilitating human diseases. Cell transplantation (regeneratve medicine) offers considerable therapeutic potential. The procedure employs pluripotent stem cells as these have the inherent ability to reproduce indefinitely and have the ability to produce over 200 different types of cells constituting the human body. The isolation of human embryonic stem cells (hESCs) from embryos and their successful culture in a petri dish in 1998 has been considered as a major breakthrough that is set to shape stem cell research in the 21st century. This has been followed by another remarkable breakthrough in 2006 when scientists demonstrated for the first time that such pluripotent stem cells could be produced from adult somatic tissues without having to use human embryos. These pluripotent stem cells are called the induced pluripotent stem (iPS) cells. Both hESCs and iPS cells - highly versatile cells – could pave the way for alleviating patients suffering from diabetes, Parkinson’s disease, Alzheimer’s disease, and many more.
This eBook brings together the information from the last decade on stem cells, compiled by reputed research experts. Readers will learn all aspects of pluripotent stem cells from basic biology to their use in understanding disease process, toxicology, drug discovery and in developing therapeutic strategies. Research on these cells, including transitional and translational aspects, is explained with the aid of extensive figures, colour photographs, and tables.
This eBook is a valuable resource for undergraduates, postgraduates, scientists, embryologists, tissue engineers, doctors and biomedical scientists interested in stem cell research and medicine.
Editor(s): Kevin R. Smith
eISBN: 978-1-60805-237-0, 2012
Sperm-mediated gene transfer (SMGT) represents a novel set of technologies for animal (or in the future, human) genetic modification using the sperm as a vector, as opposed to more traditional established routes such as fertilized eggs or embryonic stem cells.
Studies of sperm-mediated gene transfer (SMGT) indicate that sperm cells possess the ability to be utilized as carriers of exogenous genetic sequences, offering the potential of a novel cost-effective route for germline genetic modification. The fate of transgenes borne by sperm cells has been inconsistent, and analysis of offspring from SMGT experiments has shown a mixed picture in terms of genomic integration of the transgene, suggesting an episomal mode of inheritance. Various distinct steps in transgene uptake by the sperm cell have been described or proposed, including a model based upon endogenous reverse transcriptase activity. Although mature sperm cells are naturally protected against uptake of foreign nucleic acid molecules, certain environmental conditions, for example at key times within the reproductive tract, may reduce this protection, suggesting that SMGT may occasionally take place in nature. If correct, this carries profound implications for evolution and human genetic health. This e-book brings together theoretical and empirical reviews from experts in SMGT, providing comprehensive coverage of the major trends, developments and controversies in this novel field. This e-book is intended as a reference for professional researchers in the field of animal genetic modification (transgenesis) as well as teachers, scientists and physicians interested in medical genetics in general and gene therapy in particular.
Editor(s): José Ruiz-Herrera
eISBN: 978-1-60805-364-3, 2012
Dimorphism can be defined as the property of different fungal species to grow in the form of budding yeasts or in the form of mycelium, depending on the environmental conditions. Dimorphism may be considered as a differentiative phenomenon, similar to others exhibited by fungi: spore germination, sporulation, etc, but comparatively simple to analyze.
Fungal dimorphism involves extensive changes in the cell physiology and morphology in response to external signals, producing drastic alterations in the cell wall structure and synthesis, whose growth pattern changes from isodiametric (spherical) to polarized or vice versa. Because of this, dimorphism has been the subject of extensive studies as a model for the differentiation processes occurring in eukaryotic organisms.
Additionally, it is important to recall that the most important human pathogenic fungi, and some plant pathogenic ones are dimorphic, displaying different morphologies when growing as saprophytes, or inside their hosts. This observation, and the demonstration that mutants in specific genes that interfere with the dimorphic transition are non-virulent, has suggested that this process might be a target for efficient antimycotic drugs.
This e-book includes several chapters on the most important and studied fungal models, written by specialists, discussing the biology of each species or genera, the general aspects controlling their dimorphic transition, the molecular aspects involved, the use of them as models for understanding the bases of biochemical and cell differentiation, and the importance of dimorphism in pathogenesis.
This e-book is recommended for scholars and researchers working or interested in human, animal and plant pathogenesis, fungal genetics, molecular biology, development, evolution, and differentiation.
Editor(s): Ilkay Erdogan Orhan
eISBN: 978-1-60805-114-4, 2012
Modern techniques have been developed to overcome problems associated with the extraction of natural products from plants. These techniques include production of secondary metabolites by biotechnological methods such as plant tissue culture and microbial biotransformation of natural substances. Such methods have led to an increased yield of secondary metabolite amount, the discovery of new biochemical derivatives and agricultural development. For instance, use of these techniques in agricultural area have led to some beneficial traits such as formation of new varieties of known plant species, better crop quality, higher yield, better nutritive properties, more resistant species to insects and pests. Microbial biotransformation is beneficial in plant secondary metabolite production and derivatization (chemical modification of any compound made by a microorganism) and is chiefly applicable to several varieties of terpenes and steroids. This E-book demonstrates recent developments in this field. It will be of particular interest to the professionals in pharmaceutical and biotechnological industries, as well as natural product chemists, medicinal chemists, plant biochemists, and molecular biologists.
Editor(s): Julie Lafond and Cathy Vaillancourt
eISBN: 978-1-60805-372-8, 2012
Pregnancy Disorders and Perinatal Outcomes offers readers insights into knowledge related to maternal habits or disorders that could affect fetal development and lead to disability later in childhood and adulthood. It contains chapters on the role of placenta, hormones, stress, nutrition, diabetes, hypertension, in vitro fertilization, obesity, immune systems and epigenetics in pregnancy well-being and perinatal outcomes. This ebook integrates both fundamental and clinical medicine and well as molecular and cell biology. It is written in a multidisciplinary context and would be a handy reference to a wide spectrum of readers including students, clinicians (obstetricians, neonatologists, pediatricians) and basic scientists in gynecology.