ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
Aims & Scope
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eISBN: 978-1-60805-779-5, 2013
ISBN: 978-1-60805-780-1 ISSN: 2214-6318 (Print)
Frontiers in Clinical Drug Research – Central Nervous System presents the latest research and clinical studies on the central nervous system (CNS). It covers a range of topics such as the development and pathophysiology of the brain and spinal cord, physiological sites of drug action in the CNS and clinical findings on drugs used to treat CNS defects due to injury or impaired development. In addition to clinical research on humans, the book also highlights other avenues of CNS medicine and research such as pain medicine, stem cell research, pharmacology, toxicology and translational models in animals.
The first volume of the series features chapters on the following topics:
-Nerve targets in pain medicine
-Spinal cord injury
-Research on neurotoxins targeting voltage gated ion channels
-G protein coupled receptor agonists and modulators
-Drug research on mediating hypoxia in developing white matter
eISBN: 978-1-68108-189-2, 2016
ISBN: 978-1-68108-190-8 ISSN: 2467-9623 (Print) ISSN: 2214-6318 (Online)
Frontiers in Clinical Drug Research – Central Nervous System presents the latest researches and clinical studies on the central nervous system (CNS). It covers a range of topics such as the development and pathophysiology of the brain and spinal cord, physiological sites of drug action in the CNS and clinical findings on drugs used to treat CNS defects due to injury or impaired development. In addition to clinical research on humans, the book also highlights other avenues of CNS medicine and research such as pain medicine, stem cell research, pharmacology, toxicology and translational models in animals.
The second volume of the series features chapters on the following topics:
- Nucleic acids as drugs for neurodegenerative diseases
- Cellular Cysteine Network (CYSTEINET):
- Non-motor Symptoms in Parkinson’s Disease and drug therapies
- Multi-modal pharmacological treatments for major depressive disorder
Editor(s): Kenneth Berendzen
Co-Editor(s): Joachim Kilian and Dierk Wanke
eISBN: 978-1-60805-492-3, 2013
A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presents an overview of exploring gene regulatory networks, chromatin, and miRNAs. Information about state-of-the-art techniques for the determination of TF - cis-element interactions in vivo and in silico give cutting edge insights on how genomic-scale research is being approached. The Analysis of Regulatory DNA provides readers with both the necessary background knowledge and provocative, up-to-date insights aimed at sparking new and vibrant experimental designs for understanding and predicting cis-elements in the eukaryotic genome.
Editor(s): Ben M. Dunn
eISBN: 978-1-60805-487-9, 2013
ISBN: 978-1-60805-631-6 ISSN: 2213-9869 (Print)
Advances in Protein and Peptide Sciences is a book series focused on leading-edge research on the structure, physical properties, and functions of proteins and peptides. The series presents highly cited contributions first published in the journal Current Protein and Peptide Science. Authors of these contributions have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in the field of protein and peptide chemistry and molecular biology, including membrane proteins and their interactions with ligands, computational methods, and proteins in disease and biotechnology.
Editor(s): Debomoy K. Lahiri
eISBN: 978-1-60805-495-4, 2013
ISBN: 978-1-60805-714-6 ISSN: 2214-4358 (Print)
Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore, to capture and discuss both, improvements towards the diagnosis and potential treatment of AD by established and novel strategies.
This first volume of the series provides an important mechanism to bring individuals having a variety of scientific interests and expertise under one roof to specifically focus on AD and related dementias. This volume presents articles on beta amyloid protein targets as well as research on secretase enzyme systems among other topics that deal with AD therapy.
eISBN: 978-1-60805-852-5, 2014
ISBN: 978-1-60805-853-2 ISSN: 2214-4358 (Print)
Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is global – afflicting over 36 million people worldwide, with the number growing in an unabated and frightening manner. The goal of the series Advances in Alzheimer’s Research , with Volumes 1 and 2, is to provide an integrated approach to AD from basic and clinical research and to highlight the valuable information in order to unravel the origin, pathogenesis and prevention of AD. The aim of this book is to both capture and discuss improvements toward the diagnosis and potential treatment of AD by both established and novel strategies. This book series, including the Volume 2, provides an important mechanism to bring under the same roof a variety of scientific interests and expertise to specifically focus on AD and related dementias. The fullest attempt has been made to disseminate the most current knowledge on recent advances in potential therapy of AD.
Editor(s): David W.M. Leung
eISBN: 978-1-60805-787-0, 2013
Heavy metal pollution represents a global challenge to both public health and environmental sustainability. Any means to reduce heavy metal pollution in the environment is of considerable economic significance. The use of green plants to clean up heavy metal pollution is an environmentally friendly as well as a low-cost approach to the problem. This plant-based biotechnology is commonly known as ‘phytoremediation’. Presently, there is limited application of this technology because useful plants with enhanced heavy metal resistance/tolerance are still needed to assist remediation of environments polluted with heavy metals. A key to improved phytoremediation of heavy metal pollution lies in research seeking for a better understanding of the mechanism(s) of heavy metal resistance/tolerance in plants. This E-book presents a unique treatment of the topics that have never been comprehensively brought together before in a single advanced reference. The volume explores aspects of plant biology that are critical for employing phytoremedation techniques to combat heavy metal contamination such as the specific plant biology, seed biology, plant tissue culture and enzymology. This E-book will be a useful reference to plant biologists, biotechnologists and environmental engineers seeking information about phytoremediation of heavy metals from the environment.
Editor(s): Gérard Chaouat, Olivier Sandra and Nathalie Lédée
eISBN: 978-1-60805-733-7, 2013
Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by specialists in the field.
The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that Immune Molecules, and in general, transient post mating inflammatory reactions are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility.
In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break’ leads to immune abortion and the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion.
Failure of, not just, the cytokine and cell recognition mediated dialogue, but also the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological phenomenon where the once named “suppressor T cells,” re-emerge as “regulatory T cells”, and play a cardinal role.
This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs ad NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to fundamental and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.
Editor(s): Maria Letizia Gargano, Georgios I. Zervakis and Giuseppe Venturella
eISBN: 978-1-60805-800-6, 2013
First described by Giuseppe Inzenga in 1863 as “the most delicious mushroom of the Sicilian mycological flora”, Pleurotus nebrodensis remains today a prized species , especially in the Mediterranean. Pleurotus nebrodensis was sought after since ancient times as a delicious mushroom in the Madonie mountains of Sicily. Tourists and local people can appreciate the organoleptic qualities of the mushrooms in restaurants where delicious cuisine are prepared with raw or cooked mushrooms. However, its appearance and numbers are declining in nature and this species has been categorized as ‘CR’ (Critically Endangered) according to IUCN Red List Criteria. In situ conservation action for this fungus is being carried out thanks to rules issued by the Madonie Park administration prohibiting its collection as well as inoculation of roots of the associated plant C. ferulacea with grain mycelia of P. nebrodensis in the hope of increasing mushroom fructification in the wild. Ex situ conservation of P. nebrodensis has also started and involves cultivation of the mushroom in special farms in the hope of reducing collecting pressures on the species in the wild. Ex situ cultivation of P. nebrodensis also provides additional income for local farmers, who can offer a more economical product than that collected from the wild, and this in turn reduces pressure on the wild population.
This e-book is an excellent resource for amateur and professional mycologists for learning scientific information about the family Pleurotaceae with particular reference to the taxonomic group “Pleurotus on Apiaceae plants” and the “Pleurotus eryngii species-complex” and is also suitable for university students for useful insights in botany, microbiology, mycology, agronomy, and forestry.
Pleurotus Nebrodensis: A Very Special Mushroom also gives both general and specialized readers a glimpse into the selected history of mycology, folk traditions, preservation of biodiversity, sustainable development, information on mushroom cultivation techniques and alternative sources of income associated with this intriguing mushroom species.
Editor(s): Alane Beatriz Vermelho and Sonia Couri
eISBN: 978-1-60805-300-1, 2013
Methods to Determine Enzymatic Activity is a textbook about industrial enzymes. The book features definitions, classifications and applications of selected enzymes important in industry and in biotechnological processes. Analytical methods for these enzymes are also included in the text. The main objective of this textbook is to provide readers information focused on the current analysis methods of enzymatic activity at qualitative and quantitative levels. Each chapter is about one specific enzyme and contains information about its substrate and some biochemical properties. The methodologies are presented as an experimental protocol allowing interested readers to reproduce the experimental methods detailed within the textbook. These protocols contain the principle of the technique, materials, methods, and all steps necessary for the determination of enzyme activity and interpretation of results. Each methodology is illustrated with photos and schemes for a better and clear understanding. This book, therefore, uniquely brings modern analysis techniques of industrial enzymes in a single easy to understand volume. This textbook is suitable for undergraduate enzymology courses and advanced industrial biotechnology and microbiology courses.
Editor(s): Jaime Arias, Maria-Angeles Aller and Jose-Ignacio Arias
eISBN: 978-1-60805-785-6, 2013
This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple pathophysiological mechanisms making up inflammation represent the re-expression of ontogenic mechanisms during early embryo development as well as the recapitulation of ancestral phylogenetic mechanisms. The relevance of the anti-inflammatory treatments is also highlighted with respect to polytraumatic patients, advances in stem cell research, embryology and the wound healing mechanism.
Readers of this book will have the chance of gaining a unique perspective about of the pathophysiological mechanisms involved in the multiple inflammatory conditions. This integrative concept about inflammation can be applied in biological investigation, as well as in clinical research and translational medicine.
Editor(s): Christakis Constantinides
eISBN: 978-1-60805-806-8, 2014
ISBN: 978-1-60805-807-5 ISSN: 2351-9843 (Print)