ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
ISSN (Print): 2468-4228
ISSN (Online): 2468-4236
Aims & Scope
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Author(s): Chengming Wang, Bernhard Kaltenboeck and Mark D. Freeman
eISBN: 978-1-60805-348-3, 2012
PCR (Polymerase Chain Reaction) technology has become an indispensable component of routine veterinary diagnostics. However, a number of pitfalls and limiting factors affect its sensitivity and specificity of detection. It is imperative that veterinary PCR diagnosticians include such considerations in their work. Extensive experience with PCR technology in both research and diagnostic applications enables researchers to pinpoint these practical limitations, and therefore instruct the user in approaches that avoid these common errors.
This E-book discusses the basic concepts, chemistries, and instrumentation of standard and real-time PCR, and includes present applications and future perspectives for veterinary diagnostics. Critical pitfalls have been highlighted in this text with regard to veterinary PCR diagnostics which include: i) choice of platform technologies for PCR diagnosis; ii) construction of optimized PCR primers and probes to ensure its highest specificity and sensitivity; iii) correct sampling and efficient methods to preserve and release nucleic acids; iv) maximization of PCR amplification efficiency; and v) avoidance and monitoring of contamination in Veterinary PCR Diagnostics. This eBook should be a valuable reference for all veterinary professionals interested in this modern diagnostic tool.
Editor(s): Alessandra Pagliarani, Fabiana Trombetti and Vittoria Ventrella
eISBN: 978-1-60805-265-3, 2012
Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effects of organotins are unravelled in this e-book by a careful analysis of the most recent findings with special focus on contaminant action mechanisms at cellular and molecular level. The e-book provides an intriguing insight into the molecular mechanisms involved in organotin toxicology thus serving as a useful reference to biochemists, biologists, ecotoxicologists and life science students.
Editor(s): Liang Qiao
Co-Editor(s): Yumin Li, Xiang Yan and Jacob George
eISBN: 978-1-60805-072-7, 2012
Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. It should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.
Editor(s): Paulo Renato Zuquim Antas
Co-Editor(s): Dilvani Oliveira Santos, Roberta Olmo Pinheiro and Theolis Barbosa
eISBN: 978-1-60805-302-5, 2012
One of the most extraordinary characteristics of Mycobacterium tuberculosis infection is its capacity to remain within the host's tissues for a long period of time. There is an enormous reservoir of persons latently infected with tuberculosis (LTBI) estimated at about a third of the world's population. From this reservoir arise about 10 million new cases of active TB and more than two million deaths occur annually. Current Diagnosis of Infant Tuberculosis Infection covers problems concerning the diagnosis of LTBI, giving an overview of commercially available options and, unlike most reviews on this subject, also points out some tools currently under development. The Ebook provides comprehensive understandable, practice-oriented information on this subject, while keeping frontier research developments in consideration. It serves as an update to readers from universities to the research center and hospital staff - as well as a guide for helping clinicians to improve their diagnostic skills regarding TB infections in an endemic country (such as Brazil).
Author(s): Dileep K. Singh
eISBN: 978-1-60805-137-3, 2012
ISBN: 978-1-60805-531-9 ISSN: 2589-1480 (Print) ISSN: 2211-2952 (Online)
Pesticide control involves killing pest organisms or otherwise preventing them from destructive behavior. Pesticides are either natural or synthetic and are applied to target pests in a myriad of formulations (EC,WP, SP, FP, G etc.) and application technology systems (sprays, baits, slow-release diffusion, dust, etc.). In recent years, the bacterial genes coding for insecticidal proteins have been incorporated into various crops that dealt with the mortality of the pests feeding on them. Many other eco-friendly methods for insect pest control such as Integrated Pest Management (IPM), use of bio-pesticides etc., are becoming popular. Bio-pesticides and IPM should show good growth in the future, as there is growing concern for the eco-friendly organic agriculture and could be achieved through Good Agriculture Practices (GAP).
Use of pesticides requires a proper understanding of the chemistry, their handling and their use in crop protection or hygiene. These are toxic chemicals and require a good understanding of therapy and antidotes at the time of poisoning. This e-book covers pesticide chemistry, metabolic/degradation pathways, biochemical toxicology, therapy and antidotes, nano-pesticides and terminologies associated with pesticide toxicology. The book should serve as a text book for academia, or as a reference work for agriculturists, environmentalists and industry professionals.
Editor(s): Benedict C. Albensi
eISBN: 978-1-60805-257-8, 2012
The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data from their own labs and provided a perspective relevant to specific neurological diseases and potential drug targets. Historically, the transcription factor cAMP response element-binding (CREB) has been the most well documented transcription factor shown to play a role in memory. CREB has several functions, but its most notable function has to do with the formation of long-term memories. More recently, other transcription factors, such as C/EBP, Egr protein, AP-1, and NF-κB have been implicated in memory as well. Of these, scientific literature on NF-κB’s theorized role in synaptic plasticity and memory is growing rapidly. Interestingly, in some recent studies CREB and NF-κB have also been shown to interact with each other where both contribute in a cooperative fashion to the initiation of gene expression.
Editor(s): Estela Maria Novak and Eduardo Magalhães Rego
eISBN: 978-1-60805-259-2, 2012
The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in continuous progress in fundamental knowledge about molecular and cellular mechanisms in hematological neoplasia. Physiopathogenesis of Hematological Cancer presents a concise overview of the cellular and molecular biology of myelo- and Lymphoproliferative disorders. The expert reviews presented within this e-book are also accompanied by bibliographic references for relevant scientific literature. This book should prove to be a valuable reference tool for both medical graduate and postgraduates in the field of oncology.
Editor(s): Margareta Kristenson, Peter Garvin and Ulf Lundberg
eISBN: 978-1-60805-342-1, 2012
This e-book is based on a critical evaluation of existing literature on salivary cortisol, aiming to evaluate the utility of salivary cortisol as a biomarker in various settings. It focuses on how different ways of evaluating levels of salivary cortisol may have an impact on the interpretation of cortisol measurements in various contexts.
This e-book focuses on salivary cortisol in relation to the following topics: psychosocial work environment (effort reward imbalance and job demand vs control model), psychosocial resources (mastery, perceived control, sense of coherence), psychosocial risk factors (perceived stress, depression, vital exhaustion, burn-out), sleep quality, biological markers (bodily factors, cardiovascular risk factors, inflammation and metabolism) and somatic outcome.
This ebook should serve as a reference for studies planned to adopt cortisol as an assessment tool.
Editor(s): Vincenzo Vacante
Co-Editor(s): Uri Gerson
eISBN: 978-1-60805-294-3, 2012
This book presents a definitive exposition of citrus pests and their integrated, mostly non-chemical , control in the Mediterranean area. This is the first book on this topic written by experts from various countries around the Mediterranean region. It provides useful information about the different agricultural management methods and how they impact pest control on various citrus plant species and varieties grown in the aforementioned region. The volume also describes methods of pest sampling, monitoring practices and determining the pests' economic thresholds. Special features of this text include updated data on various pests, their damage and control methods, key identification methods and a relevant glossary. The e-book should be a comprehensive guide for readers interested in citrus crops and integrated pest management.
Editor(s): Toshiyuki Hata
Co-Editor(s): Asim Kurjak and Shiro Kozuma
eISBN: 978-1-60805-019-2, 2009
Editor(s): Javier Camacho
eISBN: 978-1-60805-016-1, 2012
Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecular targets and rational drug design on this molecular basis should help in discovering early cancer biomarkers as well as novel therapeutic drugs.
This book describes various cancer topics on a molecular level and integrates information on the relationship between causes of cancer, cancer cell biology, metastasis, cancer prevention and drug design. This book should prove to be an extraordinary reference text for students, physicians and oncologists.
Editor(s): Pierre Delanaye
eISBN: 978-1-60805-333-9, 2012
Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology. Patients suffering from severe chronic kidney disease may be quasi asymptomatic. This lack of overt symptomatology suggests that clinical laboratory tests are of the highest importance. Clinicians treating patients and clinical biologists operating in laboratories are often far apart from each other. They have a lot of things to share and to learn from each other. This e-book bridges the gap between these two groups of health professionals.